Continuum modeling of the electric-field-induced tension in deforming lipid vesicles

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We computationally investigate the deformation of a closed bilayer membrane (vesicle) in a DC electric pulse with a goal of understanding cell electroporation. The electric stresses exerted on the area-incompressible interface generate non-uniform tension that can exceed the membrane lysis tension and drive pore opening. Using the two-dimensional boundary integral method, we track the spatial and temporal evolution of the highest membrane tension. Our simulations highlight the dynamic nature of electrotension and, in contrast to the common assumption, a possibility of electroporation away from the poles.

Original languageEnglish (US)
Article number243132
JournalJournal of Chemical Physics
Volume143
Issue number24
DOIs
StatePublished - Dec 28 2015

Fingerprint

continuum modeling
lipids
Electric fields
membranes
Membranes
Lipids
electric fields
boundary integral method
electric pulses
Poles
poles
direct current
porosity
cells
simulation

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

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Continuum modeling of the electric-field-induced tension in deforming lipid vesicles. / McConnell, Lane C.; Miksis, Michael J.; Vlahovska, Petia M.

In: Journal of Chemical Physics, Vol. 143, No. 24, 243132, 28.12.2015.

Research output: Contribution to journalArticle

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