Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals

Jarad A. Mason; Christine R. Laramy; Cheng Tsung Lai; Matthew N. O’Brien; Qing Yuan Lin; Vinayak P. Dravid; George C. Schatz; Chad A. Mirkin

doi:10.1201/9781003056706-62

Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals

Jarad A. Mason, Christine R. Laramy, Cheng Tsung Lai, Matthew N. O’Brien, Qing Yuan Lin, Vinayak P. Dravid, George C. Schatz, Chad A. Mirkin^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

DNA surface ligands can be used as programmable “bonds” to control the arrangement of nanoparticles into crystalline superlattices. Here, 1070we study the intrinsic responsiveness of these DNA bonds to changes in local dielectric constant (er) as a new approach to dynamically modulate superlattice structure. Remarkably, ethanol (EtOH) addition can be used to controllably tune DNA bond length from 16 to 3 nm and to increase bond stability by >40°C, while retaining long-range order and crystal habit. Interestingly, we find that these structural changes, which involve the expansion and contraction of crystals by up to 75% in volume, occur in a cooperative fashion once a critical percentage of EtOH is reached. These results provide a facile and robust approach to create stimuli-responsive lattices, to access high volume fractions, and to improve thermal stability.

Original language	English (US)
Title of host publication	Spherical Nucleic Acids
Subtitle of host publication	Volume 3
Publisher	Jenny Stanford Publishing
Pages	1069-1079
Number of pages	11
Volume	3
ISBN (Electronic)	9781000092486
ISBN (Print)	9789814877237
DOIs	https://doi.org/10.1201/9781003056706-62
State	Published - Jan 1 2021

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Engineering
General Chemistry

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title = "Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals",

abstract = "DNA surface ligands can be used as programmable “bonds” to control the arrangement of nanoparticles into crystalline superlattices. Here, 1070we study the intrinsic responsiveness of these DNA bonds to changes in local dielectric constant (er) as a new approach to dynamically modulate superlattice structure. Remarkably, ethanol (EtOH) addition can be used to controllably tune DNA bond length from 16 to 3 nm and to increase bond stability by >40°C, while retaining long-range order and crystal habit. Interestingly, we find that these structural changes, which involve the expansion and contraction of crystals by up to 75\% in volume, occur in a cooperative fashion once a critical percentage of EtOH is reached. These results provide a facile and robust approach to create stimuli-responsive lattices, to access high volume fractions, and to improve thermal stability.",

author = "Mason, \{Jarad A.\} and Laramy, \{Christine R.\} and Lai, \{Cheng Tsung\} and O{\textquoteright}Brien, \{Matthew N.\} and Lin, \{Qing Yuan\} and Dravid, \{Vinayak P.\} and Schatz, \{George C.\} and Mirkin, \{Chad A.\}",

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T1 - Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals

AU - Mason, Jarad A.

AU - Laramy, Christine R.

AU - Lai, Cheng Tsung

AU - O’Brien, Matthew N.

AU - Lin, Qing Yuan

AU - Dravid, Vinayak P.

AU - Schatz, George C.

AU - Mirkin, Chad A.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - DNA surface ligands can be used as programmable “bonds” to control the arrangement of nanoparticles into crystalline superlattices. Here, 1070we study the intrinsic responsiveness of these DNA bonds to changes in local dielectric constant (er) as a new approach to dynamically modulate superlattice structure. Remarkably, ethanol (EtOH) addition can be used to controllably tune DNA bond length from 16 to 3 nm and to increase bond stability by >40°C, while retaining long-range order and crystal habit. Interestingly, we find that these structural changes, which involve the expansion and contraction of crystals by up to 75% in volume, occur in a cooperative fashion once a critical percentage of EtOH is reached. These results provide a facile and robust approach to create stimuli-responsive lattices, to access high volume fractions, and to improve thermal stability.

AB - DNA surface ligands can be used as programmable “bonds” to control the arrangement of nanoparticles into crystalline superlattices. Here, 1070we study the intrinsic responsiveness of these DNA bonds to changes in local dielectric constant (er) as a new approach to dynamically modulate superlattice structure. Remarkably, ethanol (EtOH) addition can be used to controllably tune DNA bond length from 16 to 3 nm and to increase bond stability by >40°C, while retaining long-range order and crystal habit. Interestingly, we find that these structural changes, which involve the expansion and contraction of crystals by up to 75% in volume, occur in a cooperative fashion once a critical percentage of EtOH is reached. These results provide a facile and robust approach to create stimuli-responsive lattices, to access high volume fractions, and to improve thermal stability.

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Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals

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