Contralateral cerebellar hypometabolism following cerebral insult: A positron emission tomographic study

Michael Kushner*, Abass Alavi, Martin Reivich, Robert Dann, Allan Burke, Gerald Robinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Positron emission tomographic studies of 16 patients with cerebral ischemia and brain tumor showed asymmetries in cerebellar metabolism not encountered in 14 normal control subjects. An asymmetry was present in 62.5% of cases. The lower metabolic rate occurred in the cerebellar hemisphere contralateral to the cerebral lesion (p <0.001; sign test). In all cases computed tomography showed the supratentorial lesion to be unilateral and the posterior fossa contents to be unaffected. The presence of depressed cerebellar metabolism was highly associated with involvement of the contralateral parietal lobe (p <0.02; phi coefficient). The presence of a cerebellar abnormality was not related to the presence of any particular sign. Serial studies showed normalization of cerebellar metabolism over time. It is likely that this effect is a result of interruption of the functional interconnections between the cerebrum and the cerebellum.

Original languageEnglish (US)
Pages (from-to)425-434
Number of pages10
JournalAnnals of neurology
Volume15
Issue number5
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Contralateral cerebellar hypometabolism following cerebral insult: A positron emission tomographic study'. Together they form a unique fingerprint.

Cite this