Contrast agents for MRI

Emily A. Waters, Samuel A. Wickline*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalBasic research in cardiology
Volume103
Issue number2
DOIs
StatePublished - Mar 2008

Keywords

  • Molecular imaging
  • MRI
  • Nanoparticles
  • Therapy

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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