Contrast agents for MRI

Emily A. Waters; Samuel A. Wickline

doi:10.1007/s00395-008-0711-6

Contrast agents for MRI

Emily A. Waters, Samuel A. Wickline^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.

Original language	English (US)
Pages (from-to)	114-121
Number of pages	8
Journal	Basic research in cardiology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1007/s00395-008-0711-6
State	Published - Mar 2008

Keywords

Molecular imaging
MRI
Nanoparticles
Therapy

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00395-008-0711-6

Cite this

@article{e5160910a12e42b29201784a1683ad93,

title = "Contrast agents for MRI",

abstract = "Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.",

keywords = "Molecular imaging, MRI, Nanoparticles, Therapy",

author = "Waters, {Emily A.} and Wickline, {Samuel A.}",

year = "2008",

month = mar,

doi = "10.1007/s00395-008-0711-6",

language = "English (US)",

volume = "103",

pages = "114--121",

journal = "Basic research in cardiology",

issn = "0300-8428",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Contrast agents for MRI

AU - Waters, Emily A.

AU - Wickline, Samuel A.

PY - 2008/3

Y1 - 2008/3

N2 - Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.

AB - Molecular imaging is a rapidly growing field with the potential to revolutionize cardiovascular medicine by shifting diagnostic focus from functional abnormalities which occur late in a disease process to the biochemical events which precipitate the earliest stages of disease. MRI is a modality well suited to this task as it allows a variety of contrast mechanisms for detection of epitopes of interest, as well as high-resolution anatomical localization and functional information. In this review, we discuss the widerange of available molecular MRI contrast agents and their application to diseases such as atherosclerosis, thrombus imaging, and stem cell tracking, along with opportunities for molecularly targeted drug delivery.

KW - Molecular imaging

KW - MRI

KW - Nanoparticles

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=40549113000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549113000&partnerID=8YFLogxK

U2 - 10.1007/s00395-008-0711-6

DO - 10.1007/s00395-008-0711-6

M3 - Review article

C2 - 18324367

AN - SCOPUS:40549113000

SN - 0300-8428

VL - 103

SP - 114

EP - 121

JO - Basic research in cardiology

JF - Basic research in cardiology

IS - 2

ER -

Contrast agents for MRI

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this