To the Editor: Neither the two papers on contrast medium–induced nephrotoxicity (Jan. 19 issue)12 nor the accompanying editorial3 took into account the possible influence of drug therapy (particularly, treatment with calcium-channel blockers or furosemide). The editorial3 stated that contrast medium–induced renal vasoconstriction could cause hypoxia in the renal medulla (the part of the kidney most vulnerable to ischemia), and that this effect may be central to the resulting nephrotoxicity. It is now well recognized that calcium antagonists may alter such injurious effects.4 They are potent renal vasodilators, particularly when renal vascular tone is increased.5 Moreover, these agents may redistribute renal.
ASJC Scopus subject areas
- General Medicine