TY - JOUR
T1 - Contribution of bradykinin to the cardioprotective effects of ACE inhibitors
AU - Murphey, L.
AU - Vaughan, D.
AU - Brown, N.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/1
Y1 - 2003/1
N2 - Bradykinin, through its B2 receptor, stimulates endothelial release of a number of vasodilators, such as nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor (EDHF). Angiotensin-converting enzyme (ACE) inhibitors enhance the effects of local bradykinin by decreasing its degradation and by increasing B2 receptor sensitivity. Clinical and experimental studies demonstrate that blockade of the B2 receptor attenuates the antihypertensive, antihypertrophic, and antiatherosclerotic effects of ACE inhibitors. Thus, the evidence strongly supports a role for bradykinin in mediating the cardiovascular benefits of ACE inhibitors.
AB - Bradykinin, through its B2 receptor, stimulates endothelial release of a number of vasodilators, such as nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor (EDHF). Angiotensin-converting enzyme (ACE) inhibitors enhance the effects of local bradykinin by decreasing its degradation and by increasing B2 receptor sensitivity. Clinical and experimental studies demonstrate that blockade of the B2 receptor attenuates the antihypertensive, antihypertrophic, and antiatherosclerotic effects of ACE inhibitors. Thus, the evidence strongly supports a role for bradykinin in mediating the cardiovascular benefits of ACE inhibitors.
KW - ACE inhibitors
KW - Bradykinin
KW - Endothelial dysfunction
KW - Kallikrein-kinin system
KW - Ramipril
KW - Renin-angiotensin system
UR - http://www.scopus.com/inward/record.url?scp=0037251039&partnerID=8YFLogxK
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U2 - 10.1016/S1520-765X(03)90062-9
DO - 10.1016/S1520-765X(03)90062-9
M3 - Article
AN - SCOPUS:0037251039
SN - 1520-765X
VL - 5
SP - A37-A41
JO - European Heart Journal, Supplement
JF - European Heart Journal, Supplement
IS - A
ER -