Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys

Eun Young Kim; Ronald S. Veazey; Roland Zahn; Kimberly J. McEvers; Susanne H.C. Baumeister; Gabriel J. Foster; Melisa D. Rett; Michael H. Newberg; Marcelo J. Kuroda; E. Peter Rieber; Michael Piatak; Jeffrey D. Lifson; Norman L. Letvin; Steven M. Wolinsky; Jörn E. Schmitz

doi:10.1128/JVI.02749-07

Contribution of CD8⁺ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys

Eun Young Kim^*, Ronald S. Veazey, Roland Zahn, Kimberly J. McEvers, Susanne H.C. Baumeister, Gabriel J. Foster, Melisa D. Rett, Michael H. Newberg, Marcelo J. Kuroda, E. Peter Rieber, Michael Piatak, Jeffrey D. Lifson, Norman L. Letvin, Steven M. Wolinsky, Jörn E. Schmitz

^*Corresponding author for this work

Medicine, Infectious Diseases Division

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Abstract

Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8⁺ lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8⁺ lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.

Original language	English (US)
Pages (from-to)	5631-5635
Number of pages	5
Journal	Journal of virology
Volume	82
Issue number	11
DOIs	https://doi.org/10.1128/JVI.02749-07
State	Published - Jun 2008

ASJC Scopus subject areas

Insect Science
Virology
Microbiology
Immunology

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Kim, E. Y., Veazey, R. S., Zahn, R., McEvers, K. J., Baumeister, S. H. C., Foster, G. J., Rett, M. D., Newberg, M. H., Kuroda, M. J., Rieber, E. P., Piatak, M., Lifson, J. D., Letvin, N. L., Wolinsky, S. M., & Schmitz, J. E. (2008). Contribution of CD8⁺ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys. Journal of virology, 82(11), 5631-5635. https://doi.org/10.1128/JVI.02749-07

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title = "Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys",

abstract = "Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8+ lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8+ lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.",

author = "Kim, {Eun Young} and Veazey, {Ronald S.} and Roland Zahn and McEvers, {Kimberly J.} and Baumeister, {Susanne H.C.} and Foster, {Gabriel J.} and Rett, {Melisa D.} and Newberg, {Michael H.} and Kuroda, {Marcelo J.} and Rieber, {E. Peter} and Michael Piatak and Lifson, {Jeffrey D.} and Letvin, {Norman L.} and Wolinsky, {Steven M.} and Schmitz, {J{\"o}rn E.}",

year = "2008",

month = jun,

doi = "10.1128/JVI.02749-07",

language = "English (US)",

volume = "82",

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Kim, EY, Veazey, RS, Zahn, R, McEvers, KJ, Baumeister, SHC, Foster, GJ, Rett, MD, Newberg, MH, Kuroda, MJ, Rieber, EP, Piatak, M, Lifson, JD, Letvin, NL, Wolinsky, SM & Schmitz, JE 2008, 'Contribution of CD8⁺ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys', Journal of virology, vol. 82, no. 11, pp. 5631-5635. https://doi.org/10.1128/JVI.02749-07

Contribution of CD8⁺ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys. / Kim, Eun Young; Veazey, Ronald S.; Zahn, Roland et al.
In: Journal of virology, Vol. 82, No. 11, 06.2008, p. 5631-5635.

Research output: Contribution to journal › Article › peer-review

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AU - Rieber, E. Peter

AU - Piatak, Michael

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Contribution of CD8⁺ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys

Abstract

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