Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys

Eun Young Kim*, Ronald S. Veazey, Roland Zahn, Kimberly J. McEvers, Susanne H.C. Baumeister, Gabriel J. Foster, Melisa D. Rett, Michael H. Newberg, Marcelo J. Kuroda, E. Peter Rieber, Michael Piatak, Jeffrey D. Lifson, Norman L. Letvin, Steven M. Wolinsky, Jörn E. Schmitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8+ lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8+ lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.

Original languageEnglish (US)
Pages (from-to)5631-5635
Number of pages5
JournalJournal of virology
Volume82
Issue number11
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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