Contribution of chitinases to listeria monocytogenes pathogenesis

Swarnava Chaudhuri; Joseph C. Bruno; Francis Alonzo; Bobbi Xayarath; Nicholas P. Cianciotto; Nancy E. Freitag

doi:10.1128/AEM.01338-10

Contribution of chitinases to listeria monocytogenes pathogenesis

Swarnava Chaudhuri, Joseph C. Bruno, Francis Alonzo, Bobbi Xayarath, Nicholas P. Cianciotto, Nancy E. Freitag

Microbiology-Immunology

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66 Scopus citations

Abstract

Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

Original language	English (US)
Pages (from-to)	7302-7305
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	76
Issue number	21
DOIs	https://doi.org/10.1128/AEM.01338-10
State	Published - Nov 2010

Funding

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Food Science
Biotechnology
Ecology

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abstract = "Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.",

author = "Swarnava Chaudhuri and Bruno, {Joseph C.} and Francis Alonzo and Bobbi Xayarath and Cianciotto, {Nicholas P.} and Freitag, {Nancy E.}",

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AU - Chaudhuri, Swarnava

AU - Bruno, Joseph C.

AU - Alonzo, Francis

AU - Xayarath, Bobbi

AU - Cianciotto, Nicholas P.

AU - Freitag, Nancy E.

PY - 2010/11

Y1 - 2010/11

N2 - Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

AB - Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

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Contribution of chitinases to listeria monocytogenes pathogenesis

Abstract

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