Contribution of chitinases to listeria monocytogenes pathogenesis

Swarnava Chaudhuri, Joseph C. Bruno, Francis Alonzo, Bobbi Xayarath, Nicholas P. Cianciotto, Nancy E. Freitag

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

Original languageEnglish (US)
Pages (from-to)7302-7305
Number of pages4
JournalApplied and Environmental Microbiology
Volume76
Issue number21
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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