Contribution of chitinases to listeria monocytogenes pathogenesis

Swarnava Chaudhuri, Joseph C. Bruno, Francis Alonzo, Bobbi Xayarath, Nicholas P. Cianciotto, Nancy E. Freitag

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

Original languageEnglish (US)
Pages (from-to)7302-7305
Number of pages4
JournalApplied and Environmental Microbiology
Issue number21
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Food Science
  • Biotechnology
  • Ecology


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