Contribution of epithelial-mesenchymal transition to pancreatic cancer progression

Seth B. Krantz; Mario A. Shields; Surabhi Dangi-Garimella; David J. Bentrem; Hidayatullah G. Munshi

doi:10.3390/cancers2042084

Contribution of epithelial-mesenchymal transition to pancreatic cancer progression

Seth B. Krantz, Mario A. Shields, Surabhi Dangi-Garimella, David J. Bentrem, Hidayatullah G. Munshi

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

Original language	English (US)
Pages (from-to)	2084-2097
Number of pages	14
Journal	Cancers
Volume	2
Issue number	4
DOIs	https://doi.org/10.3390/cancers2042084
State	Published - Dec 2010

Keywords

Epithelial-mesenchymal transition microRNA
Pancreatic cancer
Stem cells drug resistance

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers2042084

Cite this

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title = "Contribution of epithelial-mesenchymal transition to pancreatic cancer progression",

abstract = "Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.",

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AU - Krantz, Seth B.

AU - Shields, Mario A.

AU - Dangi-Garimella, Surabhi

AU - Bentrem, David J.

AU - Munshi, Hidayatullah G.

PY - 2010/12

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N2 - Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

AB - Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

KW - Epithelial-mesenchymal transition microRNA

KW - Pancreatic cancer

KW - Stem cells drug resistance

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Contribution of epithelial-mesenchymal transition to pancreatic cancer progression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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