Contribution of epithelial-mesenchymal transition to pancreatic cancer progression

Seth B. Krantz, Mario A. Shields, Surabhi Dangi-Garimella, David J. Bentrem, Hidayatullah G. Munshi

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)2084-2097
Number of pages14
JournalCancers
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2010

Fingerprint

Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
Survival
MicroRNAs
Adenocarcinoma
Transcription Factors
Stem Cells
Maintenance
Neoplasm Metastasis
Morbidity
Drug Therapy
Mortality
Neoplasms

Keywords

  • Epithelial-mesenchymal transition microRNA
  • Pancreatic cancer
  • Stem cells drug resistance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Contribution of epithelial-mesenchymal transition to pancreatic cancer progression",
abstract = "Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5{\%}. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.",
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Contribution of epithelial-mesenchymal transition to pancreatic cancer progression. / Krantz, Seth B.; Shields, Mario A.; Dangi-Garimella, Surabhi; Bentrem, David J.; Munshi, Hidayatullah G.

In: Cancers, Vol. 2, No. 4, 01.12.2010, p. 2084-2097.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Contribution of epithelial-mesenchymal transition to pancreatic cancer progression

AU - Krantz, Seth B.

AU - Shields, Mario A.

AU - Dangi-Garimella, Surabhi

AU - Bentrem, David J.

AU - Munshi, Hidayatullah G.

PY - 2010/12/1

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N2 - Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

AB - Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

KW - Epithelial-mesenchymal transition microRNA

KW - Pancreatic cancer

KW - Stem cells drug resistance

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