Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression

Seth B. Krantz*, Mario A. Shields, Surabhi Dangi-Garimella, Hidayatullah G. Munshi, David J. Bentrem

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

Pancreatic adenocarcinoma remains among the most lethal of human malignancies. Overall 5-y survival is less than 5%, and only 20% of patients presenting with localized disease amenable to surgical resection. Even in patients who undergo resection, long-term survival remains extremely poor. A major contributor to the aggressiveness of multiple cancers, and pancreatic cancer in particular, is the process of epithelial-to-mesenchymal transition (EMT). This review highlights the growing evidence of EMT in pancreatic cancer progression, focusing on the contribution of EMT to the development of cancer stem cells and on interaction of EMT with other pathways central to cancer progression, such as Hedgehog signaling, the K-ras oncogene, and transforming growth factor-beta (TGF-β). We will also discuss EMT-targeting agents currently in development and in clinical trials that may help to reduce the morbidity and mortality associated with pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalJournal of Surgical Research
Volume173
Issue number1
DOIs
StatePublished - Mar 1 2012

Keywords

  • drug resistance
  • epithelial-mesenchymal transition
  • microRNA
  • pancreatic cancer
  • stem cells

ASJC Scopus subject areas

  • Surgery

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