TY - JOUR
T1 - Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression
AU - Krantz, Seth B.
AU - Shields, Mario A.
AU - Dangi-Garimella, Surabhi
AU - Munshi, Hidayatullah G.
AU - Bentrem, David J.
PY - 2012/3
Y1 - 2012/3
N2 - Pancreatic adenocarcinoma remains among the most lethal of human malignancies. Overall 5-y survival is less than 5%, and only 20% of patients presenting with localized disease amenable to surgical resection. Even in patients who undergo resection, long-term survival remains extremely poor. A major contributor to the aggressiveness of multiple cancers, and pancreatic cancer in particular, is the process of epithelial-to-mesenchymal transition (EMT). This review highlights the growing evidence of EMT in pancreatic cancer progression, focusing on the contribution of EMT to the development of cancer stem cells and on interaction of EMT with other pathways central to cancer progression, such as Hedgehog signaling, the K-ras oncogene, and transforming growth factor-beta (TGF-β). We will also discuss EMT-targeting agents currently in development and in clinical trials that may help to reduce the morbidity and mortality associated with pancreatic cancer.
AB - Pancreatic adenocarcinoma remains among the most lethal of human malignancies. Overall 5-y survival is less than 5%, and only 20% of patients presenting with localized disease amenable to surgical resection. Even in patients who undergo resection, long-term survival remains extremely poor. A major contributor to the aggressiveness of multiple cancers, and pancreatic cancer in particular, is the process of epithelial-to-mesenchymal transition (EMT). This review highlights the growing evidence of EMT in pancreatic cancer progression, focusing on the contribution of EMT to the development of cancer stem cells and on interaction of EMT with other pathways central to cancer progression, such as Hedgehog signaling, the K-ras oncogene, and transforming growth factor-beta (TGF-β). We will also discuss EMT-targeting agents currently in development and in clinical trials that may help to reduce the morbidity and mortality associated with pancreatic cancer.
KW - drug resistance
KW - epithelial-mesenchymal transition
KW - microRNA
KW - pancreatic cancer
KW - stem cells
UR - http://www.scopus.com/inward/record.url?scp=84857052013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857052013&partnerID=8YFLogxK
U2 - 10.1016/j.jss.2011.09.020
DO - 10.1016/j.jss.2011.09.020
M3 - Review article
C2 - 22099597
AN - SCOPUS:84857052013
SN - 0022-4804
VL - 173
SP - 105
EP - 112
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -
