Contributions of Eosinophils to Human Health and Disease

Amy D. Klion, Steven J. Ackerman, Bruce S. Bochner

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The human eosinophil has long been thought to favorably influence innate mucosal immunity but at times has also been incriminated in disease pathophysiology. Research into eosinophil biology has uncovered a number of interesting contributions by eosinophils to health and disease. However, it appears that not all eosinophils from all species are created equal. It remains unclear, for example, exactly how having eosinophils benefits the human host when helminth infections in the developed world have become scarce. This review focuses on our current state of knowledge as it relates to human eosinophils. When information is lacking, we discuss lessons learned from mouse studies that may or may not directly apply to human biology and disease. It is an exciting time to be an quot eosinophilosopher quot because the use of biologic agents that selectively target eosinophils provides an unprecedented opportunity to define the contribution of this cell to eosinophil-associated human diseases.

Original languageEnglish (US)
Pages (from-to)179-209
Number of pages31
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume15
DOIs
StatePublished - Jan 24 2020

Keywords

  • eosinophil, hematopoiesis, cytokines, phenotype, function, eosinophil-related diseases, hypereosinophilic syndrome, biomarkers, biologic agents, treatments

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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