Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

Kristina M. Dameron, Olga V. Volpert, Michael A. Tainsky, Noël Bouck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1285 Scopus citations

Abstract

As normal cells progress toward malignancy, they must switch to an angiogenic phenotype to attract the nourishing vasculature that they depend on for their growth. In cultured fibroblasts from Li-Fraumeni patients, this switch was found to coincide with loss of the wild-type allele of the p53 tumor suppressor gene and to be the result of reduced expression of thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis. Transfection assays revealed that p53 can stimulate the endogenous TSP-1 gene and positively regulate TSP-1 promoter sequences. These data indicate that, in fibroblasts, wild-type p53 inhibits angiogenesis through regulation of TSP-1 synthesis.

Original languageEnglish (US)
Pages (from-to)1582-1584
Number of pages3
JournalScience
Volume265
Issue number5178
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • General

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