Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation

Zhong Zheng; Linda Zhang; Xiao Long Cui; Xianbin Yu; Phillip J. Hsu; Ruitu Lyu; Haiyan Tan; Malay Mandal; Michelle Zhang; Hui Lung Sun; Arantxa Sanchez Castillo; Junmin Peng; Marcus R. Clark; Chuan He; Haochu Huang

doi:10.1016/j.celrep.2020.107819

Control of Early B Cell Development by the RNA N⁶-Methyladenosine Methylation

Zhong Zheng, Linda Zhang, Xiao Long Cui, Xianbin Yu, Phillip J. Hsu, Ruitu Lyu, Haiyan Tan, Malay Mandal, Michelle Zhang, Hui Lung Sun, Arantxa Sanchez Castillo, Junmin Peng, Marcus R. Clark, Chuan He^*, Haochu Huang^*

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Zheng et al. show that B-cell-specific deletion of RNA m⁶A methylation writer protein METTL14 results in severe defects in B cell development. RNA m⁶A plays critical roles in regulating gene expressions and controls two major transitions of early B cell development via different mechanisms.

Original language	English (US)
Article number	107819
Journal	Cell reports
Volume	31
Issue number	13
DOIs	https://doi.org/10.1016/j.celrep.2020.107819
State	Published - Jun 30 2020

Keywords

B cell development
METTL14
Post-transcriptional regulation of gene expression
RNA mA modification
YTHDF2

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.107819

Cite this

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title = "Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation",

abstract = "Zheng et al. show that B-cell-specific deletion of RNA m6A methylation writer protein METTL14 results in severe defects in B cell development. RNA m6A plays critical roles in regulating gene expressions and controls two major transitions of early B cell development via different mechanisms.",

keywords = "B cell development, METTL14, Post-transcriptional regulation of gene expression, RNA mA modification, YTHDF2",

author = "Zhong Zheng and Linda Zhang and Cui, {Xiao Long} and Xianbin Yu and Hsu, {Phillip J.} and Ruitu Lyu and Haiyan Tan and Malay Mandal and Michelle Zhang and Sun, {Hui Lung} and {Sanchez Castillo}, Arantxa and Junmin Peng and Clark, {Marcus R.} and Chuan He and Haochu Huang",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

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doi = "10.1016/j.celrep.2020.107819",

language = "English (US)",

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T1 - Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation

AU - Zheng, Zhong

AU - Zhang, Linda

AU - Cui, Xiao Long

AU - Yu, Xianbin

AU - Hsu, Phillip J.

AU - Lyu, Ruitu

AU - Tan, Haiyan

AU - Mandal, Malay

AU - Zhang, Michelle

AU - Sun, Hui Lung

AU - Sanchez Castillo, Arantxa

AU - Peng, Junmin

AU - Clark, Marcus R.

AU - He, Chuan

AU - Huang, Haochu

PY - 2020/6/30

Y1 - 2020/6/30

N2 - Zheng et al. show that B-cell-specific deletion of RNA m6A methylation writer protein METTL14 results in severe defects in B cell development. RNA m6A plays critical roles in regulating gene expressions and controls two major transitions of early B cell development via different mechanisms.

AB - Zheng et al. show that B-cell-specific deletion of RNA m6A methylation writer protein METTL14 results in severe defects in B cell development. RNA m6A plays critical roles in regulating gene expressions and controls two major transitions of early B cell development via different mechanisms.

KW - B cell development

KW - METTL14

KW - Post-transcriptional regulation of gene expression

KW - RNA mA modification

KW - YTHDF2

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