Control of elongation by RNA polymerase II

Joan W. Conaway*, Ali Shilatifard, Arik Dvir, Ronald C. Conaway

*Corresponding author for this work

Research output: Contribution to journalReview article

176 Scopus citations

Abstract

The elongation stage of eukaryotic mRNA synthesis can be regulated by transcription factors that interact directly with the RNA polymerase II (pol II) elongation complex and by activities that modulate the structure of its chromatin template. Recent studies have revealed new elongation factors and have implicated the general initiation factors TFIIE, TFIIF and TFIIH, as well as the C-terminal domain (CTD) of the largest subunit of pol II, in elongation. The recently reported high-resolution crystal structure of RNA polymerase II, which provides insight into the architecture of the elongation complex, marks a new era of investigation into transcription elongation. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalTrends in Biochemical Sciences
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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