Control of interleukin 1 (IL-1) activity. I. Inhibition of IL-1 activity by soluble immune response suppressor (SIRS) in vitro

M. Zimecki*, Z. Wieczorek, C. W. Pierce, J. A. Kapp, H. W. Schnaper, D. R. Webb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Soluble immune response suppressor (SIRS)2, a nonspecific inhibitor of cellular and humoral immune responses and cellular proliferation, reversed IL-1-induced inhibition of autologous rosette formation by thymocytes. In addition, SIRS prevented the IL-1-induced increases in resistance of thymocytes to the lytic action of hydrocortisone. Kinetic experiments showed that the action of SIRS on thymocytes was rapid (less than 15 minutes), although a longer time was required to exert protective effects on thymocytes. SIRS also inhibited the stimulation of thymocyte proliferation induced by Con A and IL-1 a costimulatory assay of IL-1 activity. Moreover, SIRS inhibited the IL-1-stimulated expression of complement receptors on neonatal B cells. The inhibitory effects of SIRS were selectively directed towards IL-1, since SIRS did not interfere with induction of LAK cells by IL-2, and did not reverse inhibition of autologous rosette formation induced by factors other than IL-1, such as IL-4, a proline rich polypeptide and lactoferrin. The results presented in this report demonstrate that SIRS may be a selective inhibitor of IL-1 activity with respect to T and B cells, rendering the unresponsive to IL-1 activation and/or maturation signals.

Original languageEnglish (US)
Pages (from-to)213-226
Number of pages14
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume39
Issue number3
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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