Control of nanoparticle assembly by using DNA-modified diatom templates

Nathaniel L. Rosi, C. Shad Thaxton, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


Microorganisms point the way: The silica cell walls of various diatoms were covalently functionalized with DNA by using straightforward chemical procedures and then used as templates for the sequence-specific assembly and 3D hierarchical arrangement of prefabricated DNA-modified gold nanoparticles. The DNA was used to further direct the assembly of multiple nanoparticle layers onto the diatom templates (see picture).

Original languageEnglish (US)
Pages (from-to)5500-5503
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number41
StatePublished - Oct 18 2004


  • DNA
  • Microorganism
  • Nanostructures
  • Self-assembly
  • Template synthesis

ASJC Scopus subject areas

  • Chemistry(all)

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