Control of the shape of a thrombus-neointima-like structure by blood shear stress

Shu Qian Liu*, L. Zhong, J. Goldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Fluid mechanical factors are thought to influence vascular morphogenesis. Here we show how blood shear stress regulates the shape of a thrombus -neointima-like tissue on a polymer micro-cylinder implanted in the center of the rat vena cava with the microcylinder perpendicular to blood flow. In this model, the micro-cylinder is exposed to a laminar flow with a known shear stressfield in the leading region and a vortex flow in the trailing region. At 1, 5, 10, 20, and 30 days after implantation, it was found that the micro-cylinder was encapsulated by a thrombus-neointima-like tissue with a streamlined body profile. The highest growth rate of the thrombus-neointima-like tissue was found along the trailing and leading stagnation edges of the micro-cylinder. Blood shear stress in the laminar flow region was inversely correlated with the rate of thrombus formation and cell proliferation, and the percentage of smooth muscle a actin-positive cells. These biological changes were also found in the trailing vortex flow region, which was associated with lowered shear stress. These results suggest that blood shear stress regulates the rate of thrombus and neointimal formation and, thus, influences the shape of the thrombus-neointima-like structure in the present model.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalJournal of Biomechanical Engineering
Issue number1
StatePublished - Mar 4 2002


  • Neointimal Morphogenesis
  • SMC Proliferation
  • Vortex Blood Flow

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)


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