CONTROLLED TRIAL OF DEXAMETHASONE THERAPY IN INFANTS WITH BRONCHOPULMONARY DYSPLASIA

MarkC Mammel, DanaE Johnson, ThomasP Green, TheodoreR Thompson

Research output: Contribution to journalArticle

212 Scopus citations

Abstract

Dexamethasone was compared with placebo in a double-blind, crossover, randomised study of infants with severe bronchopulmonary dysplasia who had required mechanical ventilation for at least four weeks, despite treatment with diuretics, methylxanthines, bronchodilators, fluid restriction, nutritional supplementation, and ligation of the patent ductus arteriosus when indicated. Gestational age ranged from 27 to 33 weeks and birth weight from 800 to 1730 g. Patients received dexamethasone (0·5 mg/kg/day) or normal saline for the first 3 days, then treatment was crossed over for the next 3 days. The study was terminated when sequential analysis showed that all six patients had improved during dexamethasone therapy. Significant improvements were seen in ventilator-determined respiratory rate, peak inspiratory pressure, fractional inspired oxygen concentration, and alveolar arterial oxygen gradients (p<0·05). Although dexamethasone hastened weaning from mechanical ventilation, infection occurred in a substantial proportion of patients.

Original languageEnglish (US)
Pages (from-to)1356-1358
Number of pages3
JournalThe Lancet
Volume321
Issue number8338
DOIs
StatePublished - Jun 18 1983

ASJC Scopus subject areas

  • Medicine(all)

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