Controlling and switching the morphology of micellar nanoparticles with enzymes

Ti Hsuan Ku, Miao Ping Chien, Matthew P. Thompson, Robert S. Sinkovits, Norman H. Olson, Timothy S. Baker, Nathan C. Gianneschi

Research output: Contribution to journalArticlepeer-review

140 Scopus citations

Abstract

Micelles were prepared from polymer-peptide block copolymer amphiphiles containing substrates for protein kinase A, protein phosphatase-1, and matrix metalloproteinases 2 and 9. We examine reversible switching of the morphology of these micelles through a phosphorylation-dephosphorylation cycle and study peptide-sequence directed changes in morphology in response to proteolysis. Furthermore, the exceptional uniformity of these polymer-peptide particles makes them amenable to cryo-TEM reconstruction techniques lending insight into their internal structure.

Original languageEnglish (US)
Pages (from-to)8392-8395
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number22
DOIs
StatePublished - Jun 8 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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