Controlling influenza virus replication by inhibiting its proton channel

Lawrence H. Pinto*, Robert A. Lamb

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations

Abstract

Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalMolecular bioSystems
Volume3
Issue number1
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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