Controlling TIME: How MNK kinases function to shape tumor immunity

Thao N.D. Pham*, Christina Spaulding, Hidayatullah G. Munshi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

A number of studies have clearly established the oncogenic role for MAPK-interacting protein kinases (MNK) in human malignancies. Modulation of MNK activity affects translation of mRNAs involved in cancer development, progression, and resistance to therapies. As a result, there are ongoing efforts to develop and evaluate MNK inhibitors for cancer treatment. However, it is important to recognize that MNK activity also plays an important role in regulating the innate and adaptive immune systems. A better understanding of the role of MNK kinases and MNK-mediated signals in regulating the immune system could help mitigate undesired side effects while maximizing therapeutic efficacy of MNK inhibitors. Here, we provide a systematic review on the function of MNK kinases and their substrates in immune cells.

Original languageEnglish (US)
Article number2096
Pages (from-to)1-19
Number of pages19
JournalCancers
Volume12
Issue number8
DOIs
StatePublished - Aug 2020

Keywords

  • EIF4E
  • HnRNP A1
  • Lymphocytes
  • MNK kinases
  • Macrophages
  • Neutrophils
  • Sprouty
  • Tumor immune microenvironment (TIME), immune responses

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Controlling TIME: How MNK kinases function to shape tumor immunity'. Together they form a unique fingerprint.

Cite this