Abstract
A number of studies have clearly established the oncogenic role for MAPK-interacting protein kinases (MNK) in human malignancies. Modulation of MNK activity affects translation of mRNAs involved in cancer development, progression, and resistance to therapies. As a result, there are ongoing efforts to develop and evaluate MNK inhibitors for cancer treatment. However, it is important to recognize that MNK activity also plays an important role in regulating the innate and adaptive immune systems. A better understanding of the role of MNK kinases and MNK-mediated signals in regulating the immune system could help mitigate undesired side effects while maximizing therapeutic efficacy of MNK inhibitors. Here, we provide a systematic review on the function of MNK kinases and their substrates in immune cells.
| Original language | English (US) |
|---|---|
| Article number | 2096 |
| Pages (from-to) | 1-19 |
| Number of pages | 19 |
| Journal | Cancers |
| Volume | 12 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2020 |
Funding
Funding: This work was supported by NIH/NCI grant R01CA217907 (to H.G.M.), a Merit award I01BX002922 (to H.G.M.) from the Department of Veterans Affairs, and NIH/NCI training grant T32CA070085 (to T.N.D.P). This work was supported by NIH/NCI grant R01CA217907 (to H.G.M.), a Merit award I01BX002922 (to H.G.M.) from the Department of Veterans Affairs, and NIH/NCI training grant T32CA070085 (to T.N.D.P).
Keywords
- EIF4E
- HnRNP A1
- Lymphocytes
- MNK kinases
- Macrophages
- Neutrophils
- Sprouty
- Tumor immune microenvironment (TIME), immune responses
ASJC Scopus subject areas
- Oncology
- Cancer Research
