Convection-enhanced and local delivery of targeted cytotoxins in the treatment of malignant gliomas

Kenji Muro, Sunit Das, Jeffrey J. Raizer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Despite advances in our knowledge about the genesis, molecular biology, and natural history of malignant gliomas and the use of a multi-disciplinary approach to their treatment, patients harboring this diagnosis continue to face a grim prognosis. At the time of diagnosis, patients typically undergo surgery for the establishment of a histologic diagnosis, the reduction of tumor burden, and the relief of mass effect, with the maintenance of the patient's neurological function in mind. This is followed by the administration of adjuvant therapeutics, including radiation therapy and chemotherapy. Many investigational agents with laboratory evidence of efficacy against malignant gliomas have not met their promise in the clinical setting, largely due to the barriers that they must overcome to reach the tumor at a therapeutically meaningful concentration for a durable period of time. The relevant aspects of the blood-brain barrier, blood-tumor barrier, and blood-cerebrospinal fluid barrier, as they pertain to the delivery of agents to the tumor, will be discussed along with the strategies devised to circumvent them. This discussion will be followed by a description of agents currently in preclinical and clinical development, many of which are the result of intense ongoing research into the molecular biology of gliomas.

Original languageEnglish (US)
Pages (from-to)201-213
Number of pages13
JournalTechnology in Cancer Research and Treatment
Volume5
Issue number3
DOIs
StatePublished - Jun 2006

Keywords

  • Brain tumor
  • Convection-enhanced
  • Glioma
  • Local delivery
  • Targeted cytotoxin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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