Convection-Enhanced Delivery

A. M. Mehta, A. M. Sonabend, J. N. Bruce*

*Corresponding author for this work

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood–brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations. CED is a broadly applicable technique that can be used to deliver a variety of therapeutic compounds for a diversity of diseases, including malignant gliomas, Parkinson’s disease, and Alzheimer’s disease. While a number of technological advances have been made since its development in the early 1990s, clinical trials with CED have been largely unsuccessful, and have illuminated a number of parameters that still need to be addressed for successful clinical application. This review addresses the physical principles behind CED, limitations in the technique, as well as means to overcome these limitations, clinical trials that have been performed, and future developments.

Original languageEnglish (US)
Pages (from-to)358-371
Number of pages14
JournalNeurotherapeutics
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2017

Keywords

  • Blood–brain barrier
  • Central nervous system
  • Convection-enhanced delivery
  • Drug delivery
  • Malignant gliomas
  • Technique

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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