Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment

Guifa Xi; Erik Robinson; Barbara Mania-Farnell; Elio Fausto Vanin; Kyu Won Shim; Tsurubuchi Takao; Elise Victoria Allender; Chandra Shekhar Mayanil; Marcelo Bento Soares; Dean Ho; Tadanori Tomita

doi:10.1016/j.nano.2013.07.013

Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment

Guifa Xi^*, Erik Robinson, Barbara Mania-Farnell, Elio Fausto Vanin, Kyu Won Shim, Tsurubuchi Takao, Elise Victoria Allender, Chandra Shekhar Mayanil, Marcelo Bento Soares, Dean Ho, Tadanori Tomita

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

This study examined a novel drug delivery system for treatment of malignant brain gliomas: DOX complexed with nanodiamonds (ND-Dox), and administered via convection-enhanced delivery (CED). Drug retention and toxicity were examined in glioma cell lines, and distribution, retention and toxicity were examined in normal rat parenchyma. Efficacy was assessed in a bioluminescence rodent tumor model. NDs markedly enhanced DOX uptake and retention in glioma cells. ND-Dox delivered via CED extended DOX retention and localized DOX toxicity in normal rodent parenchyma, and was significantly more efficient at killing tumor cells than uncomplexed DOX. Outcomes from this work suggest that CED of ND-Dox is a promising approach for brain tumor treatment. From the Clinical Editor: In this paper, nanodiamonds were utilized to enhance delivery of DOX in a preclinical glioma model using a convection-enhanced delivery method, demonstrating remarkably enhanced efficacy.

Original language	English (US)
Pages (from-to)	381-391
Number of pages	11
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/j.nano.2013.07.013
State	Published - Feb 2014

Keywords

Convection-enhanced delivery (CED)
Doxorubicin (Dox)
Glioma
Nanodiamonds (NDs)

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
Materials Science(all)
Pharmaceutical Science

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Xi, Guifa ; Robinson, Erik ; Mania-Farnell, Barbara ; Vanin, Elio Fausto ; Shim, Kyu Won ; Takao, Tsurubuchi ; Allender, Elise Victoria ; Mayanil, Chandra Shekhar ; Soares, Marcelo Bento ; Ho, Dean ; Tomita, Tadanori. / Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2014 ; Vol. 10, No. 2. pp. 381-391.

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abstract = "This study examined a novel drug delivery system for treatment of malignant brain gliomas: DOX complexed with nanodiamonds (ND-Dox), and administered via convection-enhanced delivery (CED). Drug retention and toxicity were examined in glioma cell lines, and distribution, retention and toxicity were examined in normal rat parenchyma. Efficacy was assessed in a bioluminescence rodent tumor model. NDs markedly enhanced DOX uptake and retention in glioma cells. ND-Dox delivered via CED extended DOX retention and localized DOX toxicity in normal rodent parenchyma, and was significantly more efficient at killing tumor cells than uncomplexed DOX. Outcomes from this work suggest that CED of ND-Dox is a promising approach for brain tumor treatment. From the Clinical Editor: In this paper, nanodiamonds were utilized to enhance delivery of DOX in a preclinical glioma model using a convection-enhanced delivery method, demonstrating remarkably enhanced efficacy.",

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author = "Guifa Xi and Erik Robinson and Barbara Mania-Farnell and Vanin, {Elio Fausto} and Shim, {Kyu Won} and Tsurubuchi Takao and Allender, {Elise Victoria} and Mayanil, {Chandra Shekhar} and Soares, {Marcelo Bento} and Dean Ho and Tadanori Tomita",

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Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment. / Xi, Guifa; Robinson, Erik; Mania-Farnell, Barbara; Vanin, Elio Fausto; Shim, Kyu Won; Takao, Tsurubuchi; Allender, Elise Victoria; Mayanil, Chandra Shekhar; Soares, Marcelo Bento; Ho, Dean; Tomita, Tadanori.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 10, No. 2, 02.2014, p. 381-391.

Research output: Contribution to journal › Article › peer-review

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AU - Robinson, Erik

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AU - Vanin, Elio Fausto

AU - Shim, Kyu Won

AU - Takao, Tsurubuchi

AU - Allender, Elise Victoria

AU - Mayanil, Chandra Shekhar

AU - Soares, Marcelo Bento

AU - Ho, Dean

AU - Tomita, Tadanori

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