Conventional and Novel Approaches to Immunosuppression

Timothy Floreth; Sangeeta M. Bhorade; Vivek N. Ahya

doi:10.1016/j.ccm.2011.02.012

Conventional and Novel Approaches to Immunosuppression

Timothy Floreth, Sangeeta M. Bhorade, Vivek N. Ahya^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Immunosuppressive therapy has contributed significantly to improved survival after solid organ transplantation. Nevertheless, treatment-related adverse events and persistently high risk of chronic graft rejection remain major obstacles to long-term survival after lung transplantation. The development of new agents, refinements in techniques to monitor immunosuppression, and enhanced understanding of transplant immunobiology are essential for further improvements in outcome. In this article, conventional immunosuppressive regimens, novel approaches to preventing graft rejection, and investigational agents for solid organ transplantation are reviewed.

Original language	English (US)
Pages (from-to)	265-277
Number of pages	13
Journal	Clinics in Chest Medicine
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.ccm.2011.02.012
State	Published - Jun 2011

Keywords

Immunosuppression
Induction therapy
Lung transplantation
Therapeutic drug monitoring

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccm.2011.02.012

Cite this

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title = "Conventional and Novel Approaches to Immunosuppression",

abstract = "Immunosuppressive therapy has contributed significantly to improved survival after solid organ transplantation. Nevertheless, treatment-related adverse events and persistently high risk of chronic graft rejection remain major obstacles to long-term survival after lung transplantation. The development of new agents, refinements in techniques to monitor immunosuppression, and enhanced understanding of transplant immunobiology are essential for further improvements in outcome. In this article, conventional immunosuppressive regimens, novel approaches to preventing graft rejection, and investigational agents for solid organ transplantation are reviewed.",

keywords = "Immunosuppression, Induction therapy, Lung transplantation, Therapeutic drug monitoring",

author = "Timothy Floreth and Bhorade, {Sangeeta M.} and Ahya, {Vivek N.}",

year = "2011",

month = jun,

doi = "10.1016/j.ccm.2011.02.012",

language = "English (US)",

volume = "32",

pages = "265--277",

journal = "Clinics in Chest Medicine",

issn = "0272-5231",

publisher = "W.B. Saunders",

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TY - JOUR

T1 - Conventional and Novel Approaches to Immunosuppression

AU - Floreth, Timothy

AU - Bhorade, Sangeeta M.

AU - Ahya, Vivek N.

PY - 2011/6

Y1 - 2011/6

N2 - Immunosuppressive therapy has contributed significantly to improved survival after solid organ transplantation. Nevertheless, treatment-related adverse events and persistently high risk of chronic graft rejection remain major obstacles to long-term survival after lung transplantation. The development of new agents, refinements in techniques to monitor immunosuppression, and enhanced understanding of transplant immunobiology are essential for further improvements in outcome. In this article, conventional immunosuppressive regimens, novel approaches to preventing graft rejection, and investigational agents for solid organ transplantation are reviewed.

AB - Immunosuppressive therapy has contributed significantly to improved survival after solid organ transplantation. Nevertheless, treatment-related adverse events and persistently high risk of chronic graft rejection remain major obstacles to long-term survival after lung transplantation. The development of new agents, refinements in techniques to monitor immunosuppression, and enhanced understanding of transplant immunobiology are essential for further improvements in outcome. In this article, conventional immunosuppressive regimens, novel approaches to preventing graft rejection, and investigational agents for solid organ transplantation are reviewed.

KW - Immunosuppression

KW - Induction therapy

KW - Lung transplantation

KW - Therapeutic drug monitoring

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U2 - 10.1016/j.ccm.2011.02.012

DO - 10.1016/j.ccm.2011.02.012

M3 - Review article

C2 - 21511089

AN - SCOPUS:79954593191

SN - 0272-5231

VL - 32

SP - 265

EP - 277

JO - Clinics in Chest Medicine

JF - Clinics in Chest Medicine

IS - 2

ER -

Conventional and Novel Approaches to Immunosuppression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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