Convergent cortical innervation of striatal projection neurons

Geraldine J. Kress; Naoki Yamawaki; David L. Wokosin; Ian R. Wickersham; Gordon M.G. Shepherd; D. James Surmeier

doi:10.1038/nn.3397

Convergent cortical innervation of striatal projection neurons

Geraldine J. Kress, Naoki Yamawaki, David L. Wokosin, Ian R. Wickersham, Gordon M.G. Shepherd, D. James Surmeier^*

^*Corresponding author for this work

Physiology

Research output: Contribution to journal › Article

88 Scopus citations

Abstract

Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	Nature Neuroscience
Volume	16
Issue number	6
DOIs	https://doi.org/10.1038/nn.3397
State	Published - Jun 1 2013

ASJC Scopus subject areas

Neuroscience(all)

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