Convergent cortical innervation of striatal projection neurons

Geraldine J. Kress, Naoki Yamawaki, David L. Wokosin, Ian R. Wickersham, Gordon M.G. Shepherd, D. James Surmeier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalNature neuroscience
Issue number6
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Neuroscience(all)


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