Convergent cortical innervation of striatal projection neurons

Geraldine J. Kress; Naoki Yamawaki; David L. Wokosin; Ian R. Wickersham; Gordon M.G. Shepherd; D. James Surmeier

doi:10.1038/nn.3397

Convergent cortical innervation of striatal projection neurons

Geraldine J. Kress, Naoki Yamawaki, David L. Wokosin, Ian R. Wickersham, Gordon M.G. Shepherd, D. James Surmeier^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	Nature neuroscience
Volume	16
Issue number	6
DOIs	https://doi.org/10.1038/nn.3397
State	Published - Jun 2013

Funding

We thank S. Ulrich, K. Saporito, Y. Chen and L. Fisher for animal husbandry and genotyping, as well as members of the Shepherd and Surmeier laboratories for helpful discussions. We thank H.S. Seung (Massachusetts Institute of Technology) for providing the virus. This work is supported by grants from the National Institute of Neurological Disorders and Stroke (T32NS041234 to G.J.K., R01NS034696 to D.J. S., R01NS061963 to G.M.G.S. and P30NS054850 to D.L.W.), the CHDI Foundation and the JPB Foundation.

ASJC Scopus subject areas

General Neuroscience

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title = "Convergent cortical innervation of striatal projection neurons",

abstract = "Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.",

author = "Kress, {Geraldine J.} and Naoki Yamawaki and Wokosin, {David L.} and Wickersham, {Ian R.} and Shepherd, {Gordon M.G.} and Surmeier, {D. James}",

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AU - Surmeier, D. James

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Convergent cortical innervation of striatal projection neurons

Abstract

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ASJC Scopus subject areas

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