Converse conformational control of smoothened activity by structurally related small molecules

Keyphrases

• Small Molecules 100%
• Hedgehog 100%
• Conformational Control 100%
• Biological Processes 50%
• Malignancy 50%
• Gli1 50%
• Transmembrane Protein 50%
• Hedgehog Signaling Pathway 50%
• In Vitro Biochemical Assay 50%
• Protein Conformation 50%
• Structural Analogues 50%
• Methyl Groups 50%
• Combinational 50%
• Propyl 50%
• Small Molecule Libraries 50%
• Transgenic Zebrafish 50%
• Animal Development 50%
• Opposite Effects 50%
• Allyl Group 50%
• Smoothened Inhibitor 50%
• Conformational Regulation 50%
• Smoothened Agonist 50%
• Smoothened Antagonist 50%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Hedgehog 100%
• Hedgehog Signaling Pathway 50%
• Agonist 50%
• Biological Phenomena and Functions Concerning the Entire Organism 50%
• Protein Conformation 50%
• Transgenic Zebrafish 50%
• Molecular Library 50%
• Transmembrane Protein 50%
• Membrane Protein 50%

Immunology and Microbiology

• Hedgehog 100%
• Hedgehog Signaling 50%
• Agonist 50%
• Biological Phenomena and Functions Concerning the Entire Organism 50%
• Protein Conformation 50%
• Molecular Library 50%
• Transgenic Zebrafish 50%