Conversion to resectability by intra-arterial infusion chemotherapy after failure of systemic chemotherapy

E. S. Golladay*, D. L. Mollitt, P. K. Osteen, N. P. Lang, D. H. Berry, R. Neuberg, M. Kletzel

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A 17 cm hepatoblastoma was unresectable at initial exploration. Multiagent chemotherapy (ADR, CTX, VCR, 5FU, BLEO) incurred minimal response at 5 months. Infuse-A-Ports were placed in each hepatic artery and FUDR infused intermittently but there was no response at 6 weeks. Adriamycin and vincristine were then begun via the Infuse-A-Port, with prompt regression of the tumor mass. The intra-arterial course was continued 3 months. Repeat arteriography showed vascular distortion but exploration revealed no gross tumor. A persistent alpha-feto-protein elevation prompted repeat arteriography4 months afterward. A 3 cm calcific tumor was removed via an extended left lobectomy. Selective hepatic arterial infusion appeared to potentiate chemotherapy after systemic chemotherapy had failed to produce sufficient cytoreduction to allow safe surgical excision. The intra-arterial chemotherapy for unresectable hepatoblastoma warrants further investigation.

Original languageEnglish (US)
Pages (from-to)715-717
Number of pages3
JournalJournal of pediatric surgery
Volume20
Issue number6
DOIs
StatePublished - Dec 1985

Keywords

  • Hepatoblastoma

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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