Convulsive disorders: Status epilepticus

Thomas P Bleck*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Status epilepticus (SE) remains one of the most serious disorders affecting the central nervous system. Recent progress in understanding the mechanisms of the brain damage produced by SE make even more apparent the need to quickly terminate this condition, prevent its recurrence, and treat its complications. Intracellular calcium concentrations rise, prompting a cascade of excitotoxic consequences. Therapy for SE currently consists of agents which stop seizures (benzodiazepines, phenytoin, barbiturates). This review discusses their use in SE.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalClinical neuropharmacology
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1991

Keywords

  • Anticonvulsant
  • Excitotoxicity
  • Lorazepam
  • Pentobarbital
  • Phenytoin
  • Status epilepticus

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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