Cooperative Lewis acid/N-heterocyclic carbene catalysis

Daniel T. Cohen, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

416 Scopus citations


Lewis acid activation with N-heterocyclic carbene (NHC) catalysis has presented new opportunities for enantioselective reaction development. Recent findings illustrate that Lewis acids can play an important role in homoenolate annulations by: enhancement of the reactivity, reversal of the diastereo- or regioselectivity, and activation of previously inactive electrophiles. Additionally, the incorporation of a Lewis acid into Brønsted base-catalyzed conjugate addition allowed for an increase in yields.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalChemical Science
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • General Chemistry


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