Abstract
Lewis acid activation with N-heterocyclic carbene (NHC) catalysis has presented new opportunities for enantioselective reaction development. Recent findings illustrate that Lewis acids can play an important role in homoenolate annulations by: enhancement of the reactivity, reversal of the diastereo- or regioselectivity, and activation of previously inactive electrophiles. Additionally, the incorporation of a Lewis acid into Brønsted base-catalyzed conjugate addition allowed for an increase in yields.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | Chemical Science |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2012 |
ASJC Scopus subject areas
- Chemistry(all)