Cooperative melting in caged dimers of rigid small molecule-DNA hybrids

Brian R. Stepp, Julianne M. Gibbs-Davis, Dorothea L.F. Koh, SonBinh Nguyen

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Rigid small-molecule DNA hybrids (rSMDHs) have been synthesized with three DNA strands attached to a rigid tris(phenylacetylene) core. When combined under dilute conditions, complementary rSMDHs form cage dimers that melt at >10 °C higher and much sharper than either unmodified DNA duplexes or rSMDH aggregates formed at higher concentrations. With a 2.97 average number of cooperative duplexes, these caged dimers constitute the first example of cooperative melting in well-defined DNA-small-molecule structures, demonstrating the important roles that local geometry and ion concentration play in the hybridization/dehybridization of DNA-based materials.

Original languageEnglish (US)
Pages (from-to)9628-9629
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number30
DOIs
StatePublished - Jul 30 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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