Cooperative melting in caged dimers of rigid small molecule-DNA hybrids

Brian R. Stepp; Julianne M. Gibbs-Davis; Dorothea L.F. Koh; Sonbinh T. Nguyen

doi:10.1021/ja801572n

Cooperative melting in caged dimers of rigid small molecule-DNA hybrids

Brian R. Stepp, Julianne M. Gibbs-Davis, Dorothea L.F. Koh, Sonbinh T. Nguyen

Chemistry

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Rigid small-molecule DNA hybrids (rSMDHs) have been synthesized with three DNA strands attached to a rigid tris(phenylacetylene) core. When combined under dilute conditions, complementary rSMDHs form cage dimers that melt at >10 °C higher and much sharper than either unmodified DNA duplexes or rSMDH aggregates formed at higher concentrations. With a 2.97 average number of cooperative duplexes, these caged dimers constitute the first example of cooperative melting in well-defined DNA-small-molecule structures, demonstrating the important roles that local geometry and ion concentration play in the hybridization/dehybridization of DNA-based materials.

Original language	English (US)
Pages (from-to)	9628-9629
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	30
DOIs	https://doi.org/10.1021/ja801572n
State	Published - Jul 30 2008

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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abstract = "Rigid small-molecule DNA hybrids (rSMDHs) have been synthesized with three DNA strands attached to a rigid tris(phenylacetylene) core. When combined under dilute conditions, complementary rSMDHs form cage dimers that melt at >10 °C higher and much sharper than either unmodified DNA duplexes or rSMDH aggregates formed at higher concentrations. With a 2.97 average number of cooperative duplexes, these caged dimers constitute the first example of cooperative melting in well-defined DNA-small-molecule structures, demonstrating the important roles that local geometry and ion concentration play in the hybridization/dehybridization of DNA-based materials.",

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AU - Gibbs-Davis, Julianne M.

AU - Koh, Dorothea L.F.

AU - Nguyen, Sonbinh T.

PY - 2008/7/30

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AB - Rigid small-molecule DNA hybrids (rSMDHs) have been synthesized with three DNA strands attached to a rigid tris(phenylacetylene) core. When combined under dilute conditions, complementary rSMDHs form cage dimers that melt at >10 °C higher and much sharper than either unmodified DNA duplexes or rSMDH aggregates formed at higher concentrations. With a 2.97 average number of cooperative duplexes, these caged dimers constitute the first example of cooperative melting in well-defined DNA-small-molecule structures, demonstrating the important roles that local geometry and ion concentration play in the hybridization/dehybridization of DNA-based materials.

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Cooperative melting in caged dimers of rigid small molecule-DNA hybrids

Abstract

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