Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C. Schatz, Sonbinh T. Nguyen

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original languageEnglish (US)
Pages (from-to)17068-17070
Number of pages3
JournalJournal of the American Chemical Society
Issue number48
StatePublished - Dec 8 2010

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


Dive into the research topics of 'Cooperative melting in caged dimers with only two DNA duplexes'. Together they form a unique fingerprint.

Cite this