COPs and POPs: Modulators of inflammasome activity

Christian Stehlik*, Andrea Dorfleutner

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

106 Scopus citations

Abstract

Inflammasomes represent12 molecular platforms for the activation of inflammatory caspases and are essential for processing and secretion of the inflammatory cytokines IL-1β and IL-18. Multiple key proteins of inflammasomes contain caspase recruitment domains (CARDs) or pyrin domains (PYDs). Dissecting CARD- and PYD-mediated interactions substantially improved our understanding of the mechanisms by which these protein platforms are activated and emphasized their essential role during the inflammatory cytokine response. However, their precise regulation is still poorly understood. A family of small proteins that are composed of either a CARD or a PYD only emerged as important inflammasome regulators. These CARD-only proteins (COPs) and PYD-only proteins (POPs) function as endogenous dominant negative proteins that modulate the activity of inflammasomes in response to pathogen infection and tissue destruction. In this review we will summarize the most recent advances in the regulation of inflammasomes and highlight their importance for immunity and inflammatory disease.

Original languageEnglish (US)
Pages (from-to)7993-7998
Number of pages6
JournalJournal of Immunology
Volume179
Issue number12
DOIs
StatePublished - Dec 15 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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