COPs and POPs Patrol Inflammasome Activation

Mohanalaxmi Indramohan, Christian Stehlik*, Andrea Dorfleutner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Sensing and responding to pathogens and tissue damage is a core mechanism of innate immune host defense, and inflammasomes represent a central cytosolic pattern recognition receptor pathway leading to the generation of the pro-inflammatory cytokines interleukin-1β and interleukin-18 and pyroptotic cell death that causes the subsequent release of danger signals to propagate and perpetuate inflammatory responses. While inflammasome activation is essential for host defense, deregulated inflammasome responses and excessive release of inflammatory cytokines and danger signals are linked to an increasing spectrum of inflammatory diseases. In this review, we will discuss recent developments in elucidating the role of PYRIN domain-only proteins (POPs) and the related CARD-only proteins (COPs) in regulating inflammasome responses and their impact on inflammatory disease.

Original languageEnglish (US)
Pages (from-to)153-173
Number of pages21
JournalJournal of Molecular Biology
Volume430
Issue number2
DOIs
StatePublished - Jan 19 2018

Keywords

  • CARD-only protein
  • Caspase-1
  • IL-1β
  • PYD-only protein
  • inflammasome

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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