Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia

Rachel Kadakia*, Denise M. Scholtens, Gerald W. Rouleau, Octavious Talbot, Olga R. Ilkayeva, Tabitha George, Jami L. Josefson

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. Study design: A cross-sectional study of 118 full-term infants born to mothers without gestational diabetes was performed. Cord blood leptin, C-peptide, acylcarnitine, and amino acid levels were measured. Body composition was measured by air displacement plethysmography. Multivariate linear regression and principal component analysis were used to analyze associations of cord blood metabolites with newborn anthropometrics, leptin, and C-peptide. Results: Acylcarnitines AC C2, AC C4-DC/Ci4-DC, and AC C8:1-OH/C6:1-DC were positively associated with leptin, and AC C14, AC C14:2, AC C16, AC C18, and AC C18:2 were negatively associated with C-peptide (P ≤.0016). Principal component analysis revealed a positive association between factor 1(AC C2, AC C3, AC C5, AC C4/Ci4, AC C4-OH, AC C4-DC/Ci4-DC, glutamate/glutamine, and glycine) and adiposity measures. Conclusions: The positive association of AC C2 and AC C4-DC/Ci4-DC levels with leptin may reflect excess fat stores, higher fatty acid oxidation rate, and mitochondrial dysfunction leading to accumulation of acylcarnitine intermediates. Principal component analysis revealed a positive association between branched chain amino acid and ketone body metabolites and adiposity, confirming prior findings in adults. Cord blood acylcarnitine profiles may identify at-risk children before obesity or insulin resistance develops.

Original languageEnglish (US)
Pages (from-to)144-149.e1
JournalJournal of Pediatrics
Volume203
DOIs
StatePublished - Dec 1 2018

Fingerprint

Adiposity
Hyperinsulinism
Fetal Blood
Leptin
Newborn Infant
C-Peptide
Principal Component Analysis
Amino Acids
Ketone Bodies
Branched Chain Amino Acids
Plethysmography
Gestational Diabetes
Pediatric Obesity
Body Composition
Glutamine
Glycine
Insulin Resistance
Glutamic Acid
Linear Models
Fatty Acids

Keywords

  • metabolomics
  • newborn adiposity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Kadakia, Rachel ; Scholtens, Denise M. ; Rouleau, Gerald W. ; Talbot, Octavious ; Ilkayeva, Olga R. ; George, Tabitha ; Josefson, Jami L. / Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia. In: Journal of Pediatrics. 2018 ; Vol. 203. pp. 144-149.e1.
@article{8540481a6c2f4589b5d0338198dbceef,
title = "Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia",
abstract = "Objective: To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. Study design: A cross-sectional study of 118 full-term infants born to mothers without gestational diabetes was performed. Cord blood leptin, C-peptide, acylcarnitine, and amino acid levels were measured. Body composition was measured by air displacement plethysmography. Multivariate linear regression and principal component analysis were used to analyze associations of cord blood metabolites with newborn anthropometrics, leptin, and C-peptide. Results: Acylcarnitines AC C2, AC C4-DC/Ci4-DC, and AC C8:1-OH/C6:1-DC were positively associated with leptin, and AC C14, AC C14:2, AC C16, AC C18, and AC C18:2 were negatively associated with C-peptide (P ≤.0016). Principal component analysis revealed a positive association between factor 1(AC C2, AC C3, AC C5, AC C4/Ci4, AC C4-OH, AC C4-DC/Ci4-DC, glutamate/glutamine, and glycine) and adiposity measures. Conclusions: The positive association of AC C2 and AC C4-DC/Ci4-DC levels with leptin may reflect excess fat stores, higher fatty acid oxidation rate, and mitochondrial dysfunction leading to accumulation of acylcarnitine intermediates. Principal component analysis revealed a positive association between branched chain amino acid and ketone body metabolites and adiposity, confirming prior findings in adults. Cord blood acylcarnitine profiles may identify at-risk children before obesity or insulin resistance develops.",
keywords = "metabolomics, newborn adiposity",
author = "Rachel Kadakia and Scholtens, {Denise M.} and Rouleau, {Gerald W.} and Octavious Talbot and Ilkayeva, {Olga R.} and Tabitha George and Josefson, {Jami L.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.jpeds.2018.07.056",
language = "English (US)",
volume = "203",
pages = "144--149.e1",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

}

Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia. / Kadakia, Rachel; Scholtens, Denise M.; Rouleau, Gerald W.; Talbot, Octavious; Ilkayeva, Olga R.; George, Tabitha; Josefson, Jami L.

In: Journal of Pediatrics, Vol. 203, 01.12.2018, p. 144-149.e1.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia

AU - Kadakia, Rachel

AU - Scholtens, Denise M.

AU - Rouleau, Gerald W.

AU - Talbot, Octavious

AU - Ilkayeva, Olga R.

AU - George, Tabitha

AU - Josefson, Jami L.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objective: To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. Study design: A cross-sectional study of 118 full-term infants born to mothers without gestational diabetes was performed. Cord blood leptin, C-peptide, acylcarnitine, and amino acid levels were measured. Body composition was measured by air displacement plethysmography. Multivariate linear regression and principal component analysis were used to analyze associations of cord blood metabolites with newborn anthropometrics, leptin, and C-peptide. Results: Acylcarnitines AC C2, AC C4-DC/Ci4-DC, and AC C8:1-OH/C6:1-DC were positively associated with leptin, and AC C14, AC C14:2, AC C16, AC C18, and AC C18:2 were negatively associated with C-peptide (P ≤.0016). Principal component analysis revealed a positive association between factor 1(AC C2, AC C3, AC C5, AC C4/Ci4, AC C4-OH, AC C4-DC/Ci4-DC, glutamate/glutamine, and glycine) and adiposity measures. Conclusions: The positive association of AC C2 and AC C4-DC/Ci4-DC levels with leptin may reflect excess fat stores, higher fatty acid oxidation rate, and mitochondrial dysfunction leading to accumulation of acylcarnitine intermediates. Principal component analysis revealed a positive association between branched chain amino acid and ketone body metabolites and adiposity, confirming prior findings in adults. Cord blood acylcarnitine profiles may identify at-risk children before obesity or insulin resistance develops.

AB - Objective: To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns. Study design: A cross-sectional study of 118 full-term infants born to mothers without gestational diabetes was performed. Cord blood leptin, C-peptide, acylcarnitine, and amino acid levels were measured. Body composition was measured by air displacement plethysmography. Multivariate linear regression and principal component analysis were used to analyze associations of cord blood metabolites with newborn anthropometrics, leptin, and C-peptide. Results: Acylcarnitines AC C2, AC C4-DC/Ci4-DC, and AC C8:1-OH/C6:1-DC were positively associated with leptin, and AC C14, AC C14:2, AC C16, AC C18, and AC C18:2 were negatively associated with C-peptide (P ≤.0016). Principal component analysis revealed a positive association between factor 1(AC C2, AC C3, AC C5, AC C4/Ci4, AC C4-OH, AC C4-DC/Ci4-DC, glutamate/glutamine, and glycine) and adiposity measures. Conclusions: The positive association of AC C2 and AC C4-DC/Ci4-DC levels with leptin may reflect excess fat stores, higher fatty acid oxidation rate, and mitochondrial dysfunction leading to accumulation of acylcarnitine intermediates. Principal component analysis revealed a positive association between branched chain amino acid and ketone body metabolites and adiposity, confirming prior findings in adults. Cord blood acylcarnitine profiles may identify at-risk children before obesity or insulin resistance develops.

KW - metabolomics

KW - newborn adiposity

UR - http://www.scopus.com/inward/record.url?scp=85053068217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053068217&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2018.07.056

DO - 10.1016/j.jpeds.2018.07.056

M3 - Article

VL - 203

SP - 144-149.e1

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -