Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries

HAPO Study Cooperative Research Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance. OBJECTIVE: To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns. DESIGN: Cross-sectional, observational study. SETTING: Hyperglycemia and Adverse Pregnancy Outcome study. PARTICIPANTS: One thousand six hundred multiethnic mother-newborn pairs. MAIN OUTCOME MEASURE: Cord blood C-peptide, birthweight, and newborn sum of skinfolds. RESULTS: Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes. CONCLUSIONS: Cord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses.

Original languageEnglish (US)
Pages (from-to)4459-4472
Number of pages14
JournalThe Journal of clinical endocrinology and metabolism
Volume104
Issue number10
DOIs
StatePublished - Oct 1 2019

Fingerprint

Metabolomics
C-Peptide
Fetal Blood
Blood
Metabolites
Newborn Infant
Adiposity
Branched Chain Amino Acids
Mothers
Nonesterified Fatty Acids
Pediatric Obesity
Hyperinsulinism
Pregnancy Outcome
Triglycerides
Fatty Acids
Hyperglycemia
Observational Studies
Insulin Resistance
Insulin
Meta-Analysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{0d7474d6fb1b468ebd71f6a3072be6b0,
title = "Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries",
abstract = "CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance. OBJECTIVE: To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns. DESIGN: Cross-sectional, observational study. SETTING: Hyperglycemia and Adverse Pregnancy Outcome study. PARTICIPANTS: One thousand six hundred multiethnic mother-newborn pairs. MAIN OUTCOME MEASURE: Cord blood C-peptide, birthweight, and newborn sum of skinfolds. RESULTS: Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes. CONCLUSIONS: Cord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses.",
author = "{HAPO Study Cooperative Research Group} and Kadakia, {Rachel Bulbul} and Octavious Talbot and Alan Kuang and Bain, {James R.} and Muehlbauer, {Michael J.} and Stevens, {Robert D.} and Ilkayeva, {Olga R.} and Lowe, {Lynn Peterson} and Metzger, {Boyd E} and Newgard, {Christopher B.} and Scholtens, {Denise M} and {Lowe Jr}, {William L}",
year = "2019",
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language = "English (US)",
volume = "104",
pages = "4459--4472",
journal = "Journal of Clinical Endocrinology and Metabolism",
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publisher = "The Endocrine Society",
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Cord Blood Metabolomics : Association With Newborn Anthropometrics and C-Peptide Across Ancestries. / HAPO Study Cooperative Research Group.

In: The Journal of clinical endocrinology and metabolism, Vol. 104, No. 10, 01.10.2019, p. 4459-4472.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cord Blood Metabolomics

T2 - Association With Newborn Anthropometrics and C-Peptide Across Ancestries

AU - HAPO Study Cooperative Research Group

AU - Kadakia, Rachel Bulbul

AU - Talbot, Octavious

AU - Kuang, Alan

AU - Bain, James R.

AU - Muehlbauer, Michael J.

AU - Stevens, Robert D.

AU - Ilkayeva, Olga R.

AU - Lowe, Lynn Peterson

AU - Metzger, Boyd E

AU - Newgard, Christopher B.

AU - Scholtens, Denise M

AU - Lowe Jr, William L

PY - 2019/10/1

Y1 - 2019/10/1

N2 - CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance. OBJECTIVE: To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns. DESIGN: Cross-sectional, observational study. SETTING: Hyperglycemia and Adverse Pregnancy Outcome study. PARTICIPANTS: One thousand six hundred multiethnic mother-newborn pairs. MAIN OUTCOME MEASURE: Cord blood C-peptide, birthweight, and newborn sum of skinfolds. RESULTS: Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes. CONCLUSIONS: Cord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses.

AB - CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance. OBJECTIVE: To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns. DESIGN: Cross-sectional, observational study. SETTING: Hyperglycemia and Adverse Pregnancy Outcome study. PARTICIPANTS: One thousand six hundred multiethnic mother-newborn pairs. MAIN OUTCOME MEASURE: Cord blood C-peptide, birthweight, and newborn sum of skinfolds. RESULTS: Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes. CONCLUSIONS: Cord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses.

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