CoRESTed development of regulatory T cells

Luisa Morales-Nebreda, Kathryn A. Helmin, Benjamin D. Singer*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Tregs require specific epigenetic signatures to induce and maintain their suppressive function in the context of inflammation and cancer surveillance. In this issue of the JCI, Xiong and colleagues identify a critical role for the epigenetic repressor REST corepressor 1 (CoREST) in promoting Treg suppressive transcriptional and functional programs. Pharmacologic inhibition and genetic loss of CoREST in Tregs impaired organ allograft tolerance and unleashed antitumor immunity via epigenetic activation of effector T cell programs. We propose that exploiting epigenetic control mechanisms will further the translation of Treg-based therapeutics to target inflammatory and malignant disorders.

Original languageEnglish (US)
Pages (from-to)1618-1621
Number of pages4
JournalJournal of Clinical Investigation
Volume130
Issue number4
DOIs
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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