TY - JOUR
T1 - Corneal epithelial biology
T2 - Lessons stemming from old to new
AU - Lavker, Robert M.
AU - Kaplan, Nihal
AU - Wang, Junyi
AU - Peng, Han
N1 - Funding Information:
This research is supported by National Institutes of Health Grants EY06769 , EY017539 and EY019463 (to R.M.L.); a Dermatology Foundation research grant and Career Development Award (to H.P.); an Eversight research grant (to H.P.), and the International Postdoctoral Exchange Fellowship Program 20180087 (to J. Wang).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/9
Y1 - 2020/9
N2 - The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying tissues from injury. Central to this protection are the corneal, limbal and conjunctival epithelia. The corneal epithelium is a self-renewing stratified squamous epithelium that protects the underlying delicate structures of the eye, supports a tear film and maintains transparency so that light can be transmitted to the interior of the eye (Basu et al., 2014; Cotsarelis et al., 1989; Funderburgh et al., 2016; Lehrer et al., 1998; Pajoohesh-Ganji and Stepp, 2005; Parfitt et al., 2015; Peng et al., 2012b; Stepp and Zieske, 2005). In this review, dedicated to James Funderburgh and his contributions to visual science, in particular the limbal niche, corneal stroma and corneal stromal stem cells, we will focus on recent data on the identification of novel regulators in corneal epithelial cell biology, their roles in stem cell homeostasis, wound healing, limbal/corneal boundary maintenance and the utility of single cell RNA sequencing (scRNA-seq) in vision biology studies.
AB - The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying tissues from injury. Central to this protection are the corneal, limbal and conjunctival epithelia. The corneal epithelium is a self-renewing stratified squamous epithelium that protects the underlying delicate structures of the eye, supports a tear film and maintains transparency so that light can be transmitted to the interior of the eye (Basu et al., 2014; Cotsarelis et al., 1989; Funderburgh et al., 2016; Lehrer et al., 1998; Pajoohesh-Ganji and Stepp, 2005; Parfitt et al., 2015; Peng et al., 2012b; Stepp and Zieske, 2005). In this review, dedicated to James Funderburgh and his contributions to visual science, in particular the limbal niche, corneal stroma and corneal stromal stem cells, we will focus on recent data on the identification of novel regulators in corneal epithelial cell biology, their roles in stem cell homeostasis, wound healing, limbal/corneal boundary maintenance and the utility of single cell RNA sequencing (scRNA-seq) in vision biology studies.
KW - Autophagy
KW - EphA2
KW - Ephrin-A1
KW - Limbal epithelial stem cells
KW - Limbal/corneal epithelial boundary
KW - Single cell RNAseq
KW - microRNAs
UR - http://www.scopus.com/inward/record.url?scp=85088514650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088514650&partnerID=8YFLogxK
U2 - 10.1016/j.exer.2020.108094
DO - 10.1016/j.exer.2020.108094
M3 - Article
C2 - 32697979
AN - SCOPUS:85088514650
SN - 0014-4835
VL - 198
JO - Experimental eye research
JF - Experimental eye research
M1 - 108094
ER -