Corneal infection with herpes simplex virus type 1 leads to autoimmune responses in rats

L. Clark*, M. Fareed, S. D. Miller, C. Merryman, E. Heber-Katz

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Lewis rats were infected by corneal scarification with HSV type 1 type strain F virus. The animals showed symptoms of infection and inflammatory infiltrates of the eye but little mortality. After one month, immune responses to viral and autoantigens were examined. It was shown that lymph node cells proliferated to the myelin antigen, proteolipoprotein, and the HSV antigen, glycoprotein D, but showed depressed responses to antigens of the eye, specifically corneal and retinal antigens. Splenic cells showed small but significant responses to antigens of the eye, indicating immune deviation similar to that previously demonstrated in ACAID, where antigen had been injected into the anterior chamber of the eye.

Original languageEnglish (US)
Pages (from-to)770-775
Number of pages6
JournalJournal of Neuroscience Research
Volume45
Issue number6
DOIs
StatePublished - Sep 15 1996

Keywords

  • HSV-1
  • Lewis rat
  • autoimmunity
  • cornea
  • optic nerve
  • retina

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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