Coronary artery calcium progression among the US and Japanese men: The MESA and SESSA

Takashi Hisamatsu*, Kiang Liu, Cheeling Chan, Amy E. Krefman, Akira Fujiyoshi, Matthew J. Budoff, Katsuyuki Miura, Donald M. Lloyd-Jones, Hirotsugu Ueshima

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods: In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results: Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions: We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

Original languageEnglish (US)
Article numbere008104
JournalCirculation: Cardiovascular Imaging
Volume12
Issue number2
DOIs
StatePublished - Feb 1 2019

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Coronary Vessels
Calcium
Hispanic Americans
Japan
Ethnic Groups
Incidence
Coronary Disease
Coronary Artery Disease
Cardiovascular Diseases
Tomography
Demography
Population

Keywords

  • Japan
  • coronary disease
  • ethnic groups
  • humans
  • risk factors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Hisamatsu, T., Liu, K., Chan, C., Krefman, A. E., Fujiyoshi, A., Budoff, M. J., ... Ueshima, H. (2019). Coronary artery calcium progression among the US and Japanese men: The MESA and SESSA. Circulation: Cardiovascular Imaging, 12(2), [e008104]. https://doi.org/10.1161/CIRCIMAGING.118.008104
Hisamatsu, Takashi ; Liu, Kiang ; Chan, Cheeling ; Krefman, Amy E. ; Fujiyoshi, Akira ; Budoff, Matthew J. ; Miura, Katsuyuki ; Lloyd-Jones, Donald M. ; Ueshima, Hirotsugu. / Coronary artery calcium progression among the US and Japanese men : The MESA and SESSA. In: Circulation: Cardiovascular Imaging. 2019 ; Vol. 12, No. 2.
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abstract = "Background: The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods: In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results: Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2{\%}, 26.9{\%}, 29.2{\%}, 18.9{\%}, and 29.2{\%}, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95{\%} CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95{\%} CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions: We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.",
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Coronary artery calcium progression among the US and Japanese men : The MESA and SESSA. / Hisamatsu, Takashi; Liu, Kiang; Chan, Cheeling; Krefman, Amy E.; Fujiyoshi, Akira; Budoff, Matthew J.; Miura, Katsuyuki; Lloyd-Jones, Donald M.; Ueshima, Hirotsugu.

In: Circulation: Cardiovascular Imaging, Vol. 12, No. 2, e008104, 01.02.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coronary artery calcium progression among the US and Japanese men

T2 - The MESA and SESSA

AU - Hisamatsu, Takashi

AU - Liu, Kiang

AU - Chan, Cheeling

AU - Krefman, Amy E.

AU - Fujiyoshi, Akira

AU - Budoff, Matthew J.

AU - Miura, Katsuyuki

AU - Lloyd-Jones, Donald M.

AU - Ueshima, Hirotsugu

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods: In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results: Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions: We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

AB - Background: The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods: In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results: Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions: We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

KW - Japan

KW - coronary disease

KW - ethnic groups

KW - humans

KW - risk factors

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