TY - JOUR
T1 - Coronary artery disease risk in Chinese type 2 diabetics
T2 - Is there a role for paraxonase 1 gene (Q192R) polymorphism?
AU - Osei-Hyiaman, D.
AU - Hou, L.
AU - Mengbai, F.
AU - Zhiyin, R.
AU - Zhiming, Z.
AU - Kano, K.
PY - 2001
Y1 - 2001
N2 - Objective: Heredity plays an important role in the predisposition to atherosclerotic coronary artery disease (CAD), and its thrombotic complications. Paraoxonase, a high-density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, is presumed to contribute to atherosclerosis and CAD. This study investigates the role of human paraoxonase 1 (PON 1) gene (Q192R) polymorphism in CAD risk among Chinese type 2 diabetic cases. Design: A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics. Methods: Subjects included 201 angiographically documented CAD patients with type 2 diabetic and 231 control subjects with type 2 diabetes alone living in central China. Single strand conformational polymorphism (SSCP) analysis was used to screen for PON 1 gene (Q192R) polymorphism. Results: Frequency of the R allele was 21.5% in the CAD patients and 12.0% in the control subjects. The presence of the R allele was significantly associated with risk of CAD (odds ratio (OR) = 1.97; 95% confidence interval (CI) = 1.36-2.86). Conclusion: Frequency of the 192R allele of the human paraoxonase 1 gene may be an independent risk factor for CAD in the Chinese type 2 diabetics studied.
AB - Objective: Heredity plays an important role in the predisposition to atherosclerotic coronary artery disease (CAD), and its thrombotic complications. Paraoxonase, a high-density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, is presumed to contribute to atherosclerosis and CAD. This study investigates the role of human paraoxonase 1 (PON 1) gene (Q192R) polymorphism in CAD risk among Chinese type 2 diabetic cases. Design: A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics. Methods: Subjects included 201 angiographically documented CAD patients with type 2 diabetic and 231 control subjects with type 2 diabetes alone living in central China. Single strand conformational polymorphism (SSCP) analysis was used to screen for PON 1 gene (Q192R) polymorphism. Results: Frequency of the R allele was 21.5% in the CAD patients and 12.0% in the control subjects. The presence of the R allele was significantly associated with risk of CAD (odds ratio (OR) = 1.97; 95% confidence interval (CI) = 1.36-2.86). Conclusion: Frequency of the 192R allele of the human paraoxonase 1 gene may be an independent risk factor for CAD in the Chinese type 2 diabetics studied.
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U2 - 10.1530/eje.0.1440639
DO - 10.1530/eje.0.1440639
M3 - Article
C2 - 11375798
AN - SCOPUS:0034985074
VL - 144
SP - 639
EP - 644
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 6
ER -