Coronary artery disease risk in Chinese type 2 diabetics: Is there a role for paraxonase 1 gene (Q192R) polymorphism?

D. Osei-Hyiaman*, L. Hou, F. Mengbai, R. Zhiyin, Z. Zhiming, K. Kano

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Objective: Heredity plays an important role in the predisposition to atherosclerotic coronary artery disease (CAD), and its thrombotic complications. Paraoxonase, a high-density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, is presumed to contribute to atherosclerosis and CAD. This study investigates the role of human paraoxonase 1 (PON 1) gene (Q192R) polymorphism in CAD risk among Chinese type 2 diabetic cases. Design: A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics. Methods: Subjects included 201 angiographically documented CAD patients with type 2 diabetic and 231 control subjects with type 2 diabetes alone living in central China. Single strand conformational polymorphism (SSCP) analysis was used to screen for PON 1 gene (Q192R) polymorphism. Results: Frequency of the R allele was 21.5% in the CAD patients and 12.0% in the control subjects. The presence of the R allele was significantly associated with risk of CAD (odds ratio (OR) = 1.97; 95% confidence interval (CI) = 1.36-2.86). Conclusion: Frequency of the 192R allele of the human paraoxonase 1 gene may be an independent risk factor for CAD in the Chinese type 2 diabetics studied.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalEuropean Journal of Endocrinology
Volume144
Issue number6
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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