Coronary artery plaque progression and cardiovascular risk scores in men with and without HIV-infection

Kashif Shaikh*, Fiona Bhondoekhan, Sabina Haberlen, Rine Nakanishi, Sion K. Roy, Venkata M. Alla, Todd T. Brown, Juhwan Lee, Kazuhiro Osawa, Shone Almeida, Sina Rahmani, Negin Nezarat, Nasim Sheidaee, Michael Kim, Eranthi Jayawardena, Nicolas Kim, Nicolai Hathiramani, Frank J. Palella, Mallory Witt, Khadije AhmadLawrence Kingsley, Wendy S. Post, Matthew J. Budoff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: The aim of this study was to assess the association of cardiovascular disease (CVD) risk scores and coronary artery plaque (CAP) progression in HIV-infected participants. Methods: We studied men with and without HIV-infection enrolled in the Multicenter AIDS Cohort Study (MACS) CVD study. CAP at baseline and follow-up was assessed with cardiac computed tomography angiography (CCTA). We examined the association between baseline risk scores including pooled cohort equation (PCE), Framingham risk score (FRS), and Data collect of Adverse effects of anti-HIV drugs equation (D:A:D) and CAP progression. Results: We studied 495 men (211 HIV-uninfected, 284 HIV-infected). The adjusted odds ratio (aOR) of total plaque volume (TPV) and noncalcified plaque volume (NCPV) progression in the highest relative to lowest tertile was 9.4 [95% confidence interval (95% CI) 2.4 – 12.1, P < 0.001)] and 7.7 (95% CI 3.1 – 19.1, P < 0.001) times greater, respectively, among HIV-uninfected men in the PCE atherosclerotic cardiovascular disease (ASCVD) high vs. low-risk category. Among HIV-infected men, the association for TPV and NCPV progression for the same PCE risk categories, odds ratio (OR) 2.8 (95% CI 1.4 – 5.8, P < 0.01) and OR 2.4 (95% CI 1.2 – 4.8, P < 0.05), respectively (P values for interaction by HIV = 0.02 and 0.08, respectively). Similar results were seen for the FRS risk scores. Among HIV-uninfected men, PCE high risk category identified the highest proportion of men with plaque progression in the highest tertile, although in HIV-infected men, high-risk category by D:A:D identified the greatest percentage of men with plaque progression albeit with lower specificity than FRS and PCE. Conclusion: PCE and FRS categories predict CAP progression better in HIV-uninfected than in HIV-infected men. Improved CVD risk scores are needed to identify high-risk HIV-infected men for more aggressive CVD risk prevention strategies.

Original languageEnglish (US)
Pages (from-to)215-224
Number of pages10
Issue number2
StatePublished - Feb 1 2022


  • Calcified plaque
  • Cardiovascular disease risk
  • HIV
  • Noncalcified

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


Dive into the research topics of 'Coronary artery plaque progression and cardiovascular risk scores in men with and without HIV-infection'. Together they form a unique fingerprint.

Cite this