Coronary magnetic resonance angiography using magnetization-prepared contrast-enhanced breath-hold volume-targeted imaging (MPCE-VCATS)

Carina W. Yang*, James C. Carr, Christopher J. Francois, Steven M. Shea, Vibhas S. Deshpande, Sheridan N. Meyers, Nirat Beohar, J. Paul Finn, Debiao Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

OBJECTIVES: Coronary artery x-ray angiography (XRA) is currently the gold standard for the assessment of coronary artery disease. A substantial minority of patients referred for coronary angiography have no significant coronary artery disease. The purpose of this study is to evaluate magnetization-prepared contrast-enhanced breath-hold volume-targeted imaging (MPCE-VCATS), a new 3-dimensional breath-hold coronary magnetic resonance angiography (MRA) technique, in detecting hemodynamically significant coronary artery stenoses in a patient population, with XRA correlation. MATERIALS AND METHODS: A total of 19 subjects who were referred for conventional coronary angiography were enrolled in the study. ECG-triggered MPCE-VCATS coronary artery scans were acquired for the left main coronary artery (LCA), left anterior descending (LAD), and right coronary artery (RCA). Coronary MRA and XRA results were compared. RESULTS: The overall sensitivity, accuracy, and negative predictive value for diagnosing any hemodynamically significant coronary artery disease (≥50% diameter reduction) was 91%, 80%, and 90%, respectively. The sensitivity of the technique in the LCA, LAD, and RCA was 100%, 100% and 78%, respectively. The negative predictive value of the technique was 100%, 100%, and 71%, respectively. DISCUSSION: MPCE-VCATS is a promising technique for coronary artery imaging. It has a relatively high sensitivity as well as a high NPV. The results of the study may indicate a future role for the technique in obviating the need for some patients to undergo XRA.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalInvestigative radiology
Volume41
Issue number8
DOIs
StatePublished - Aug 2006

Keywords

  • Breath-hold
  • Contrast-enhanced
  • Conventional coronary artery angiography
  • Coronary artery disease
  • Magnetic resonance angiography
  • Volume-targeted

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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