Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization

Yutaka Furukawa*, Natsuhiko Ehara, Ryoji Taniguchi, Yoshisumi Haruna, Neiko Ozasa, Naritatsu Saito, Takahiro Doi, Kozo Hoshino, Toshihiro Tamura, Satoshi Shizuta, Mitsuru Abe, Masanao Toma, Takeshi Morimoto, Satoshi Teramukai, Masanori Fukushima, Toru Kita, Takeshi Kimura, Jong Dae Lee, Kuniyoshi Tanaka, Katsuo OkazakiMasaaki Takahashi, Teiji Oda, Shigeo Matsui, Naohiro Ohashi, Eiichi Matsuyama, Makoto Kadoya, Yoshiki Takatsu, Shinichi Nomoto, Kazuaki Kataoka, Hajime Kotoura, Masaki Aota, Akira Miura, Satoru Suwa, Chuwa Tei, Ryuzo Sakata, Shuichi Hamasaki, Hiroyuki Yamamoto, Takeshi Aoyama, Takahiro Sakurai, Mitsuo Matsuda, Masahiko Onoe, Yuzo Takeuchi, Ryuji Nohara, Kimisato Nakano, Shigefumi Morioka, Yukikatsu Okada, Kenichi Shiratori, Yasuki Kihara, Michihiro Nasu, Masakiyo Nobuyoshi, Hitoshi Okabayashi, Hitoshi Yasumoto, Jyota Nakano, Tomoyuki Murakami, Katsuya Ishida, Hisao Ogawa, Michio Kawasuji, Seigo Sugiyama, Shoichiro Hagiwara, Kazuaki Mitsudo, Tatsuhiko Komiya, Kazushige Kadota, Masashi Komeda, Ryozo Tatami, Teruaki Ushijima, Akira Yoshida, Hiroyuki Nakajima, Shinji Miki, Ryuichi Hattori, Noboru Nishiwaki, Manabu Shirotani, Hiroshi Kato, Hiroshi Eizawa, Masaru Tanaka, Kazuaki Minami, Minoru Horie, Tohru Asai, Hiroyuki Takashima, Ryuji Higashita, Mamoru Takahashi, Takafumi Tahata, Yoshiki Matoba, Kiyosbi Doyama, Makoto Araki, Akinori Takizawa, Mitsuomi Shimamoto, Fumio Yamazaki, Osamu Doi, Hirofumi Kambara, Katsuhiko Matsuda, Satoshi Kaburagi, Masafumi Nara, Masaki Kawanami, Takashi Konishi, Yoshihisa Nakagawa, Kazunobu Nishimura, Seiji Ootani, Takaaki Sugita

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. Methods and Results: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (≤55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25kg/m2, current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. Conclusions: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.

Original languageEnglish (US)
Pages (from-to)1459-1465
Number of pages7
JournalCirculation Journal
Volume73
Issue number8
DOIs
StatePublished - Aug 1 2009

Keywords

  • Chronic kidney disease
  • Coronary artery disease
  • Coronary revascularization
  • Risk factors
  • Young patients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Furukawa, Y., Ehara, N., Taniguchi, R., Haruna, Y., Ozasa, N., Saito, N., Doi, T., Hoshino, K., Tamura, T., Shizuta, S., Abe, M., Toma, M., Morimoto, T., Teramukai, S., Fukushima, M., Kita, T., Kimura, T., Lee, J. D., Tanaka, K., ... Sugita, T. (2009). Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. Circulation Journal, 73(8), 1459-1465. https://doi.org/10.1253/circj.CJ-08-1083