Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization

Yutaka Furukawa*, Natsuhiko Ehara, Ryoji Taniguchi, Yoshisumi Haruna, Neiko Ozasa, Naritatsu Saito, Takahiro Doi, Kozo Hoshino, Toshihiro Tamura, Satoshi Shizuta, Mitsuru Abe, Masanao Toma, Takeshi Morimoto, Satoshi Teramukai, Masanori Fukushima, Toru Kita, Takeshi Kimura, Jong Dae Lee, Kuniyoshi Tanaka, Katsuo OkazakiMasaaki Takahashi, Teiji Oda, Shigeo Matsui, Naohiro Ohashi, Eiichi Matsuyama, Makoto Kadoya, Yoshiki Takatsu, Shinichi Nomoto, Kazuaki Kataoka, Hajime Kotoura, Masaki Aota, Akira Miura, Satoru Suwa, Chuwa Tei, Ryuzo Sakata, Shuichi Hamasaki, Hiroyuki Yamamoto, Takeshi Aoyama, Takahiro Sakurai, Mitsuo Matsuda, Masahiko Onoe, Yuzo Takeuchi, Ryuji Nohara, Kimisato Nakano, Shigefumi Morioka, Yukikatsu Okada, Kenichi Shiratori, Yasuki Kihara, Michihiro Nasu, Masakiyo Nobuyoshi, Hitoshi Okabayashi, Hitoshi Yasumoto, Jyota Nakano, Tomoyuki Murakami, Katsuya Ishida, Hisao Ogawa, Michio Kawasuji, Seigo Sugiyama, Shoichiro Hagiwara, Kazuaki Mitsudo, Tatsuhiko Komiya, Kazushige Kadota, Masashi Komeda, Ryozo Tatami, Teruaki Ushijima, Akira Yoshida, Hiroyuki Nakajima, Shinji Miki, Ryuichi Hattori, Noboru Nishiwaki, Manabu Shirotani, Hiroshi Kato, Hiroshi Eizawa, Masaru Tanaka, Kazuaki Minami, Minoru Horie, Tohru Asai, Hiroyuki Takashima, Ryuji Higashita, Mamoru Takahashi, Takafumi Tahata, Yoshiki Matoba, Kiyosbi Doyama, Makoto Araki, Akinori Takizawa, Mitsuomi Shimamoto, Fumio Yamazaki, Osamu Doi, Hirofumi Kambara, Katsuhiko Matsuda, Satoshi Kaburagi, Masafumi Nara, Masaki Kawanami, Takashi Konishi, Yoshihisa Nakagawa, Kazunobu Nishimura, Seiji Ootani, Takaaki Sugita

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. Methods and Results: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (≤55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25kg/m2, current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. Conclusions: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.

Original languageEnglish (US)
Pages (from-to)1459-1465
Number of pages7
JournalCirculation Journal
Volume73
Issue number8
DOIs
StatePublished - Aug 1 2009

Fingerprint

Coronary Artery Disease
Chronic Renal Insufficiency
Multivariate Analysis
Myocardial Infarction
Dyslipidemias
Registries
Young Adult
Body Mass Index
Stroke
Outcome Assessment (Health Care)

Keywords

  • Chronic kidney disease
  • Coronary artery disease
  • Coronary revascularization
  • Risk factors
  • Young patients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Furukawa, Y., Ehara, N., Taniguchi, R., Haruna, Y., Ozasa, N., Saito, N., ... Sugita, T. (2009). Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. Circulation Journal, 73(8), 1459-1465. https://doi.org/10.1253/circj.CJ-08-1083
Furukawa, Yutaka ; Ehara, Natsuhiko ; Taniguchi, Ryoji ; Haruna, Yoshisumi ; Ozasa, Neiko ; Saito, Naritatsu ; Doi, Takahiro ; Hoshino, Kozo ; Tamura, Toshihiro ; Shizuta, Satoshi ; Abe, Mitsuru ; Toma, Masanao ; Morimoto, Takeshi ; Teramukai, Satoshi ; Fukushima, Masanori ; Kita, Toru ; Kimura, Takeshi ; Lee, Jong Dae ; Tanaka, Kuniyoshi ; Okazaki, Katsuo ; Takahashi, Masaaki ; Oda, Teiji ; Matsui, Shigeo ; Ohashi, Naohiro ; Matsuyama, Eiichi ; Kadoya, Makoto ; Takatsu, Yoshiki ; Nomoto, Shinichi ; Kataoka, Kazuaki ; Kotoura, Hajime ; Aota, Masaki ; Miura, Akira ; Suwa, Satoru ; Tei, Chuwa ; Sakata, Ryuzo ; Hamasaki, Shuichi ; Yamamoto, Hiroyuki ; Aoyama, Takeshi ; Sakurai, Takahiro ; Matsuda, Mitsuo ; Onoe, Masahiko ; Takeuchi, Yuzo ; Nohara, Ryuji ; Nakano, Kimisato ; Morioka, Shigefumi ; Okada, Yukikatsu ; Shiratori, Kenichi ; Kihara, Yasuki ; Nasu, Michihiro ; Nobuyoshi, Masakiyo ; Okabayashi, Hitoshi ; Yasumoto, Hitoshi ; Nakano, Jyota ; Murakami, Tomoyuki ; Ishida, Katsuya ; Ogawa, Hisao ; Kawasuji, Michio ; Sugiyama, Seigo ; Hagiwara, Shoichiro ; Mitsudo, Kazuaki ; Komiya, Tatsuhiko ; Kadota, Kazushige ; Komeda, Masashi ; Tatami, Ryozo ; Ushijima, Teruaki ; Yoshida, Akira ; Nakajima, Hiroyuki ; Miki, Shinji ; Hattori, Ryuichi ; Nishiwaki, Noboru ; Shirotani, Manabu ; Kato, Hiroshi ; Eizawa, Hiroshi ; Tanaka, Masaru ; Minami, Kazuaki ; Horie, Minoru ; Asai, Tohru ; Takashima, Hiroyuki ; Higashita, Ryuji ; Takahashi, Mamoru ; Tahata, Takafumi ; Matoba, Yoshiki ; Doyama, Kiyosbi ; Araki, Makoto ; Takizawa, Akinori ; Shimamoto, Mitsuomi ; Yamazaki, Fumio ; Doi, Osamu ; Kambara, Hirofumi ; Matsuda, Katsuhiko ; Kaburagi, Satoshi ; Nara, Masafumi ; Kawanami, Masaki ; Konishi, Takashi ; Nakagawa, Yoshihisa ; Nishimura, Kazunobu ; Ootani, Seiji ; Sugita, Takaaki. / Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. In: Circulation Journal. 2009 ; Vol. 73, No. 8. pp. 1459-1465.
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abstract = "Background: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. Methods and Results: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (≤55 years; n=898; 14.3{\%}) and older (>55 years; n=5,422; 85.7{\%}) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25kg/m2, current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. Conclusions: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.",
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Furukawa, Y, Ehara, N, Taniguchi, R, Haruna, Y, Ozasa, N, Saito, N, Doi, T, Hoshino, K, Tamura, T, Shizuta, S, Abe, M, Toma, M, Morimoto, T, Teramukai, S, Fukushima, M, Kita, T, Kimura, T, Lee, JD, Tanaka, K, Okazaki, K, Takahashi, M, Oda, T, Matsui, S, Ohashi, N, Matsuyama, E, Kadoya, M, Takatsu, Y, Nomoto, S, Kataoka, K, Kotoura, H, Aota, M, Miura, A, Suwa, S, Tei, C, Sakata, R, Hamasaki, S, Yamamoto, H, Aoyama, T, Sakurai, T, Matsuda, M, Onoe, M, Takeuchi, Y, Nohara, R, Nakano, K, Morioka, S, Okada, Y, Shiratori, K, Kihara, Y, Nasu, M, Nobuyoshi, M, Okabayashi, H, Yasumoto, H, Nakano, J, Murakami, T, Ishida, K, Ogawa, H, Kawasuji, M, Sugiyama, S, Hagiwara, S, Mitsudo, K, Komiya, T, Kadota, K, Komeda, M, Tatami, R, Ushijima, T, Yoshida, A, Nakajima, H, Miki, S, Hattori, R, Nishiwaki, N, Shirotani, M, Kato, H, Eizawa, H, Tanaka, M, Minami, K, Horie, M, Asai, T, Takashima, H, Higashita, R, Takahashi, M, Tahata, T, Matoba, Y, Doyama, K, Araki, M, Takizawa, A, Shimamoto, M, Yamazaki, F, Doi, O, Kambara, H, Matsuda, K, Kaburagi, S, Nara, M, Kawanami, M, Konishi, T, Nakagawa, Y, Nishimura, K, Ootani, S & Sugita, T 2009, 'Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization', Circulation Journal, vol. 73, no. 8, pp. 1459-1465. https://doi.org/10.1253/circj.CJ-08-1083

Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization. / Furukawa, Yutaka; Ehara, Natsuhiko; Taniguchi, Ryoji; Haruna, Yoshisumi; Ozasa, Neiko; Saito, Naritatsu; Doi, Takahiro; Hoshino, Kozo; Tamura, Toshihiro; Shizuta, Satoshi; Abe, Mitsuru; Toma, Masanao; Morimoto, Takeshi; Teramukai, Satoshi; Fukushima, Masanori; Kita, Toru; Kimura, Takeshi; Lee, Jong Dae; Tanaka, Kuniyoshi; Okazaki, Katsuo; Takahashi, Masaaki; Oda, Teiji; Matsui, Shigeo; Ohashi, Naohiro; Matsuyama, Eiichi; Kadoya, Makoto; Takatsu, Yoshiki; Nomoto, Shinichi; Kataoka, Kazuaki; Kotoura, Hajime; Aota, Masaki; Miura, Akira; Suwa, Satoru; Tei, Chuwa; Sakata, Ryuzo; Hamasaki, Shuichi; Yamamoto, Hiroyuki; Aoyama, Takeshi; Sakurai, Takahiro; Matsuda, Mitsuo; Onoe, Masahiko; Takeuchi, Yuzo; Nohara, Ryuji; Nakano, Kimisato; Morioka, Shigefumi; Okada, Yukikatsu; Shiratori, Kenichi; Kihara, Yasuki; Nasu, Michihiro; Nobuyoshi, Masakiyo; Okabayashi, Hitoshi; Yasumoto, Hitoshi; Nakano, Jyota; Murakami, Tomoyuki; Ishida, Katsuya; Ogawa, Hisao; Kawasuji, Michio; Sugiyama, Seigo; Hagiwara, Shoichiro; Mitsudo, Kazuaki; Komiya, Tatsuhiko; Kadota, Kazushige; Komeda, Masashi; Tatami, Ryozo; Ushijima, Teruaki; Yoshida, Akira; Nakajima, Hiroyuki; Miki, Shinji; Hattori, Ryuichi; Nishiwaki, Noboru; Shirotani, Manabu; Kato, Hiroshi; Eizawa, Hiroshi; Tanaka, Masaru; Minami, Kazuaki; Horie, Minoru; Asai, Tohru; Takashima, Hiroyuki; Higashita, Ryuji; Takahashi, Mamoru; Tahata, Takafumi; Matoba, Yoshiki; Doyama, Kiyosbi; Araki, Makoto; Takizawa, Akinori; Shimamoto, Mitsuomi; Yamazaki, Fumio; Doi, Osamu; Kambara, Hirofumi; Matsuda, Katsuhiko; Kaburagi, Satoshi; Nara, Masafumi; Kawanami, Masaki; Konishi, Takashi; Nakagawa, Yoshihisa; Nishimura, Kazunobu; Ootani, Seiji; Sugita, Takaaki.

In: Circulation Journal, Vol. 73, No. 8, 01.08.2009, p. 1459-1465.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization

AU - Furukawa, Yutaka

AU - Ehara, Natsuhiko

AU - Taniguchi, Ryoji

AU - Haruna, Yoshisumi

AU - Ozasa, Neiko

AU - Saito, Naritatsu

AU - Doi, Takahiro

AU - Hoshino, Kozo

AU - Tamura, Toshihiro

AU - Shizuta, Satoshi

AU - Abe, Mitsuru

AU - Toma, Masanao

AU - Morimoto, Takeshi

AU - Teramukai, Satoshi

AU - Fukushima, Masanori

AU - Kita, Toru

AU - Kimura, Takeshi

AU - Lee, Jong Dae

AU - Tanaka, Kuniyoshi

AU - Okazaki, Katsuo

AU - Takahashi, Masaaki

AU - Oda, Teiji

AU - Matsui, Shigeo

AU - Ohashi, Naohiro

AU - Matsuyama, Eiichi

AU - Kadoya, Makoto

AU - Takatsu, Yoshiki

AU - Nomoto, Shinichi

AU - Kataoka, Kazuaki

AU - Kotoura, Hajime

AU - Aota, Masaki

AU - Miura, Akira

AU - Suwa, Satoru

AU - Tei, Chuwa

AU - Sakata, Ryuzo

AU - Hamasaki, Shuichi

AU - Yamamoto, Hiroyuki

AU - Aoyama, Takeshi

AU - Sakurai, Takahiro

AU - Matsuda, Mitsuo

AU - Onoe, Masahiko

AU - Takeuchi, Yuzo

AU - Nohara, Ryuji

AU - Nakano, Kimisato

AU - Morioka, Shigefumi

AU - Okada, Yukikatsu

AU - Shiratori, Kenichi

AU - Kihara, Yasuki

AU - Nasu, Michihiro

AU - Nobuyoshi, Masakiyo

AU - Okabayashi, Hitoshi

AU - Yasumoto, Hitoshi

AU - Nakano, Jyota

AU - Murakami, Tomoyuki

AU - Ishida, Katsuya

AU - Ogawa, Hisao

AU - Kawasuji, Michio

AU - Sugiyama, Seigo

AU - Hagiwara, Shoichiro

AU - Mitsudo, Kazuaki

AU - Komiya, Tatsuhiko

AU - Kadota, Kazushige

AU - Komeda, Masashi

AU - Tatami, Ryozo

AU - Ushijima, Teruaki

AU - Yoshida, Akira

AU - Nakajima, Hiroyuki

AU - Miki, Shinji

AU - Hattori, Ryuichi

AU - Nishiwaki, Noboru

AU - Shirotani, Manabu

AU - Kato, Hiroshi

AU - Eizawa, Hiroshi

AU - Tanaka, Masaru

AU - Minami, Kazuaki

AU - Horie, Minoru

AU - Asai, Tohru

AU - Takashima, Hiroyuki

AU - Higashita, Ryuji

AU - Takahashi, Mamoru

AU - Tahata, Takafumi

AU - Matoba, Yoshiki

AU - Doyama, Kiyosbi

AU - Araki, Makoto

AU - Takizawa, Akinori

AU - Shimamoto, Mitsuomi

AU - Yamazaki, Fumio

AU - Doi, Osamu

AU - Kambara, Hirofumi

AU - Matsuda, Katsuhiko

AU - Kaburagi, Satoshi

AU - Nara, Masafumi

AU - Kawanami, Masaki

AU - Konishi, Takashi

AU - Nakagawa, Yoshihisa

AU - Nishimura, Kazunobu

AU - Ootani, Seiji

AU - Sugita, Takaaki

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. Methods and Results: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (≤55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25kg/m2, current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. Conclusions: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.

AB - Background: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. Methods and Results: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (≤55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25kg/m2, current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. Conclusions: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.

KW - Chronic kidney disease

KW - Coronary artery disease

KW - Coronary revascularization

KW - Risk factors

KW - Young patients

UR - http://www.scopus.com/inward/record.url?scp=69049121413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69049121413&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-1083

DO - 10.1253/circj.CJ-08-1083

M3 - Article

C2 - 19531902

AN - SCOPUS:69049121413

VL - 73

SP - 1459

EP - 1465

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 8

ER -