Coronary thrombosis in a patient with May-Hegglin anomaly

S. McDunn, W. Hartz, C. Ts'Ao, D. Green*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


May-Hegglin anomaly (MHA) is a rare hereditary condition that is characterized by cytoplasmic inclusions in leukocytes and giant platelets. Many patients have some degree of thrombocytopenia. Most individuals with MHA are asymptomatic, but 25-43% of patients previously reported have had a hemorrhagic tendency. The authors describe a patient with MHA who had no history of hemorrhage but who developed complete coronary thrombosis after attempted angioplasty despite an apparent platelet count of 24,000 per mm3. Laboratory investigations revealed a normal bleeding time, normal platelet aggregation, and an increase in the size of approximately two-thirds of the platelets. The calculated platelet mass was near normal, which probably explains the thrombosis despite a decrease in platelet numbers. The authors conclude that in some patients with MHA platelets are functionally active both in vivo and in vitro.

Original languageEnglish (US)
Pages (from-to)715-718
Number of pages4
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 1991


  • Coronary thrombosis
  • May-Hegglin anomaly
  • Platelet function
  • Platelet mass
  • Platelet morphology
  • Thrombocytopenia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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