Coronavirus disease 2019 and kidney injury

Shweta Punj, Eudora Eng, Aneesha A. Shetty*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose of review In this paper, we seek to review coronavirus disease 2019 (COVID-19) associated kidney injury with a focus on what is known about pathophysiology. Recent findings Kidney injury is a common complication of SARS-CoV-2 infection and is associated with increased morbidity and mortality. Acute tubular necrosis and glomerular injury are two common findings. Direct viral effect, endothelial dysfunction, and podocyte and tubular epithelial injury have been described. COVID-19- related glomerular injury may also be associated with high-risk APOL1 genotype. Summary Data on COVID-19 renal involvement have suggested novel mechanisms of kidney injury that need to be further elucidated. More data are needed on renal involvement in milder disease, renal-specific therapeutic interventions, and long-term sequelae.

Original languageEnglish (US)
Pages (from-to)444-449
Number of pages6
JournalCurrent opinion in nephrology and hypertension
Volume30
Issue number4
DOIs
StatePublished - Apr 2 2021

Keywords

  • Acute kidney injury
  • Acute tubular injury
  • Acute tubular necrosis
  • Apolipoprotein L1
  • Coronavirus disease 2019
  • Glomerular injury
  • Podocytopathy
  • Renal replacement therapy
  • Severe acute respiratory syndrome coronavirus 2

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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