Correlates of rapid neuroleptic response in male patients with schizophrenia

Eric C. Petrie, William O. Faustman, James A. Moses, Leon Lombrozo, John G. Csernansky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Correlates of neuroleptic response latency were assessed in 16 male schizophrenic inpatients during 4 weeks of fixed dose (20 mg/day) haloperidol treatment. Rapid responders showed a mean 40% reduction in Brief Psychiatric Rating Scale (BPRS) positive symptom scores by day 10 of treatment. Rapid responders had significantly lower plasma homovanillic acid (pHVA) concentrations compared to non-rapid responders during week 4 of haloperidol treatment. However, rapid versus non-rapid responders did not differ with respect to demographics, baseline positive or negative BPRS symptom scores, performance on tests of neuropsychological function, or mean plasma haloperidol concentrations.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalPsychiatry Research
Volume33
Issue number2
DOIs
StatePublished - Aug 1990

Keywords

  • Homovanillic acid
  • haloperidol
  • neuropsychology
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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