Correlation and Agreement of Yttrium-90 Positron Emission Tomography/Computed Tomography with Ex Vivo Radioembolization Microsphere Deposition in the Rabbit VX2 Liver Tumor Model

Andrew C. Gordon*, Vanessa L. Gates, Sarah B. White, Kathleen R. Harris, Daniel Procissi, Zhuoli Zhang, Weiguo Li, Donald Samaan, Jodi R. Nicolai, Samdeep K. Mouli, Kent T. Sato, Robert K. Ryu, Reed A. Omary, Riad Salem, Robert J. Lewandowski, Andrew C. Larson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To demonstrate a stronger correlation and agreement of yttrium-90 (90Y) positron emission tomography (PET)/computed tomography (CT) measurements with explant liver tumor dosing compared with the standard model (SM) for radioembolization. Materials and Methods: Hepatic VX2 tumors were implanted into New Zealand white rabbits, with growth confirmed by 7 T magnetic resonance imaging. Seventeen VX2 rabbits provided 33 analyzed tumors. Treatment volumes were calculated from manually drawn volumes of interest (VOI) with three-dimensional surface renderings. Radioembolization was performed with glass 90Y microspheres. PET/CT imaging was completed with scatter and attenuation correction. Three-dimensional ellipsoid VOI were drawn to encompass tumors on fused images. Tumors and livers were then explanted for inductively coupled plasma (ICP)-optical emission spectroscopy (OES) analysis of microsphere content. 90Y PET/CT and SM measurements were compared with reference standard ICP-OES measurements of tumor dosing with Pearson correlation and Bland-Altman analyses for agreement testing with and without adjustment for tumor necrosis. Results: The median infused activity was 33.3 MBq (range, 5.9–152.9). Tumor dose was significantly correlated with 90Y PET/CT measurements (r = 0.903, P < .001) and SM estimates (r = 0.607, P < .001). Bland-Altman analyses showed that the SM tended to underestimate the tumor dosing by a mean of −8.5 Gy (CI, −26.3–9.3), and the degree of underestimation increased to a mean of −18.3 Gy (CI, −38.5–1.9) after the adjustment for tumor necrosis. Conclusions: 90Y PET/CT estimates were strongly correlated and had better agreement with reference measurements of tumor dosing than SM estimates.

Original languageEnglish (US)
Pages (from-to)23-32.e1
JournalJournal of Vascular and Interventional Radiology
Volume32
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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