Correlation between age-related changes in open field behavior and plaque forming cell response in da female rats

Čedomir Todorović, Mirjana Dimitrijević*, Stanislava Stanojević, Vesna Kovacevic-Jovanovic, Tatjana Miletić, Olgica Laban, Jelena Radulović

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.

Original languageEnglish (US)
Pages (from-to)1259-1273
Number of pages15
JournalInternational Journal of Neuroscience
Volume113
Issue number9
DOIs
StatePublished - Sep 1 2003

Keywords

  • Analgesia
  • Forced-swim test
  • Macrophages
  • Open field
  • Plaque forming cell response
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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