Correlation between fractional anisotropy and motor outcomes in one-year-old infants with periventricular brain injury

Sangeetha Madhavan, Suzann K. Campbell, Rose Campise-Luther, Deborah Gaebler-Spira, Laura Zawacki, April Clark, Kara Boynewicz, Dipti Kale, Michelle Bulanda, Jinsheng Yu, Yi Sui, Xiaohong Joe Zhou

Research output: Contribution to journalArticle

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Abstract

Purpose To determine whether motor outcomes of an exercise intervention beginning at 2 months corrected age (CA) in children with periventricular brain injury (PBI) are correlated with fractional anisotropy (FA) measures derived from diffusion tensor imaging (DTI) at 12 months CA. Materials and Methods DTI was performed in eight infants with PBI who were randomly assigned to kicking and treadmill stepping exercise or a no-training condition. Development was assessed using the Alberta Infant Motor Scale (AIMS) and the Gross Motor Function Classification System (GMFCS). FA values were derived from regions of interest (ROIs) in the middle third of the posterior limb of the internal capsule (PLIC) and the posterior thalamic radiation (PTR). Results Significant correlations were observed between motor development and FA measures. For PLIC, the correlation coefficients were 0.82 between FA and AIMS, and -0.92 between FA and GMFCS, while for PTR the corresponding correlation coefficients were 0.73 and -0.80, respectively. Conclusion Results of this study suggest that quantitative evaluation of white matter tracts using DTI at 12 months CA may be useful for assessment of brain plasticity in children.

LanguageEnglish (US)
Pages949-957
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume39
Issue number4
DOIs
StatePublished - Jan 1 2014

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Anisotropy
Brain Injuries
Diffusion Tensor Imaging
Internal Capsule
Alberta
Extremities
Exercise
Radiation
Brain

Keywords

  • DTI
  • fractional anisotropy (FA)
  • infants
  • periventricular brain injury
  • treadmill exercise

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Madhavan, Sangeetha ; Campbell, Suzann K. ; Campise-Luther, Rose ; Gaebler-Spira, Deborah ; Zawacki, Laura ; Clark, April ; Boynewicz, Kara ; Kale, Dipti ; Bulanda, Michelle ; Yu, Jinsheng ; Sui, Yi ; Zhou, Xiaohong Joe. / Correlation between fractional anisotropy and motor outcomes in one-year-old infants with periventricular brain injury. In: Journal of Magnetic Resonance Imaging. 2014 ; Vol. 39, No. 4. pp. 949-957.
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Madhavan, S, Campbell, SK, Campise-Luther, R, Gaebler-Spira, D, Zawacki, L, Clark, A, Boynewicz, K, Kale, D, Bulanda, M, Yu, J, Sui, Y & Zhou, XJ 2014, 'Correlation between fractional anisotropy and motor outcomes in one-year-old infants with periventricular brain injury' Journal of Magnetic Resonance Imaging, vol. 39, no. 4, pp. 949-957. https://doi.org/10.1002/jmri.24256

Correlation between fractional anisotropy and motor outcomes in one-year-old infants with periventricular brain injury. / Madhavan, Sangeetha; Campbell, Suzann K.; Campise-Luther, Rose; Gaebler-Spira, Deborah; Zawacki, Laura; Clark, April; Boynewicz, Kara; Kale, Dipti; Bulanda, Michelle; Yu, Jinsheng; Sui, Yi; Zhou, Xiaohong Joe.

In: Journal of Magnetic Resonance Imaging, Vol. 39, No. 4, 01.01.2014, p. 949-957.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between fractional anisotropy and motor outcomes in one-year-old infants with periventricular brain injury

AU - Madhavan, Sangeetha

AU - Campbell, Suzann K.

AU - Campise-Luther, Rose

AU - Gaebler-Spira, Deborah

AU - Zawacki, Laura

AU - Clark, April

AU - Boynewicz, Kara

AU - Kale, Dipti

AU - Bulanda, Michelle

AU - Yu, Jinsheng

AU - Sui, Yi

AU - Zhou, Xiaohong Joe

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Y1 - 2014/1/1

N2 - Purpose To determine whether motor outcomes of an exercise intervention beginning at 2 months corrected age (CA) in children with periventricular brain injury (PBI) are correlated with fractional anisotropy (FA) measures derived from diffusion tensor imaging (DTI) at 12 months CA. Materials and Methods DTI was performed in eight infants with PBI who were randomly assigned to kicking and treadmill stepping exercise or a no-training condition. Development was assessed using the Alberta Infant Motor Scale (AIMS) and the Gross Motor Function Classification System (GMFCS). FA values were derived from regions of interest (ROIs) in the middle third of the posterior limb of the internal capsule (PLIC) and the posterior thalamic radiation (PTR). Results Significant correlations were observed between motor development and FA measures. For PLIC, the correlation coefficients were 0.82 between FA and AIMS, and -0.92 between FA and GMFCS, while for PTR the corresponding correlation coefficients were 0.73 and -0.80, respectively. Conclusion Results of this study suggest that quantitative evaluation of white matter tracts using DTI at 12 months CA may be useful for assessment of brain plasticity in children.

AB - Purpose To determine whether motor outcomes of an exercise intervention beginning at 2 months corrected age (CA) in children with periventricular brain injury (PBI) are correlated with fractional anisotropy (FA) measures derived from diffusion tensor imaging (DTI) at 12 months CA. Materials and Methods DTI was performed in eight infants with PBI who were randomly assigned to kicking and treadmill stepping exercise or a no-training condition. Development was assessed using the Alberta Infant Motor Scale (AIMS) and the Gross Motor Function Classification System (GMFCS). FA values were derived from regions of interest (ROIs) in the middle third of the posterior limb of the internal capsule (PLIC) and the posterior thalamic radiation (PTR). Results Significant correlations were observed between motor development and FA measures. For PLIC, the correlation coefficients were 0.82 between FA and AIMS, and -0.92 between FA and GMFCS, while for PTR the corresponding correlation coefficients were 0.73 and -0.80, respectively. Conclusion Results of this study suggest that quantitative evaluation of white matter tracts using DTI at 12 months CA may be useful for assessment of brain plasticity in children.

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